ArticlePediatric research2025
The overlooked subgroup: preterm neonates with elevated serum creatinine outside neonatal AKI criteria.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Post-asphyxia acute kidney injury in neonates: a systematic review.European journal of pediatrics · 2026Pooled it
- From Gestational Age-Specific Serum Creatinine Trajectories to an Interactive Clinical Interpretation Tool in Level IV NICU Infants.Research square · 2026Article
- Serum creatinine: beyond renal function as a biomarker of adverse outcomes in premature neonates.Pediatric research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo characterize risks and outcomes of preterm neonates with elevated serum creatinine (SCr) not meeting acute kidney injury (AKI) criteria.
methodsThis cohort study included neonates <31 weeks' gestation admitted to a university hospital. Elevated SCr was defined as exceeding the 95th percentile for postnatal age without meeting standard AKI criteria in neonates <28 or 28-30 weeks. Perinatal/neonatal risks and discharge outcomes were compared among elevated SCr, SCr-AKI, and no SCr-AKI subgroups.
resultsAmong 810 infants, 156 had SCr-AKI, 623 had no SCr-AKI, and 31 had elevated SCr. Compared to no SCr-AKI, the elevated SCr subgroup had lower birthweight, higher rates of small-for-gestational-age, respiratory distress, hemodynamic instability, prolonged invasive ventilation, lower anthropometric z-scores, and higher mortality, despite similar gestational age. Compared to SCr-AKI, they had higher gestational age and higher rates of small-for-gestational-age, with similar mortality. Adjusted models showed elevated SCr (adjusted relative risk [aRR], 3.74) and SCr-AKI (aRR, 3.95) predicted higher mortality versus no SCr-AKI.
conclusionGestational age-specific SCr references are critical for identifying preterm neonates with elevated SCr levels outside AKI criteria, who face neonatal risks and distinct mortality outcomes. IMPACT STATEMENT: The risks and outcomes of preterm neonates with elevated serum creatinine (SCr) levels that do not meet Kidney Disease: Improving Global Outcomes (KDIGO) acute kidney injury (AKI) criteria require further investigation. These neonates have distinct exposure profiles compared to those with KDIGO SCr-AKI and a poorer prognosis than those without SCr-AKI. They also have higher mortality than neonates without SCr-AKI. Our findings highlight the importance of gestational age-specific SCr reference values in neonatal care to better identify at-risk preterm infants beyond KDIGO criteria, enabling early intervention and improved outcomes.
Identifiers
40962862What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.