Evidence map›Paper›PMID 40962842›Full record

ArticleNature communications2025

Cofactor-independent photo-enzymatic reductions with water mediated by reductive graphene quantum dots.

Anming Wang, Xiaoyu Li, Li Qiao, Xiaoting Pan, Yongjian Jiang, Zhiguo Wang, Wei Ye, Peng Gao, Roger A Sheldon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anming Wang *Key Laboratory of Organosilicon Chemistry and Materials Technology, Ministry of Education; College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China. waming@hznu.edu.
Xiaoyu Li *Key Laboratory of Organosilicon Chemistry and Materials Technology, Ministry of Education; College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China.ORCID http://orcid.org/0000-0001-8884-9428
Li QiaoKey Laboratory of Organosilicon Chemistry and Materials Technology, Ministry of Education; College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China. 11837066@zju.edu.cn.
Xiaoting PanKey Laboratory of Organosilicon Chemistry and Materials Technology, Ministry of Education; College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China.
Yongjian JiangKey Laboratory of Organosilicon Chemistry and Materials Technology, Ministry of Education; College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China.
Zhiguo WangZhejiang Key Laboratory of Medical Epigenetics, Institute of Aging Research, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China. zhgwang@hznu.edu.cn.ORCID http://orcid.org/0000-0001-8732-4451
Wei YeKey Laboratory of Organosilicon Chemistry and Materials Technology, Ministry of Education; College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China. yewei@hznu.edu.cn.ORCID http://orcid.org/0000-0003-4905-2015
Peng GaoKey Laboratory of Organosilicon Chemistry and Materials Technology, Ministry of Education; College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China. gaopeng@hrbeu.edu.cn.ORCID http://orcid.org/0000-0002-8742-2833
Roger A SheldonMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits., 2050, Johannesburg, South Africa. roger.sheldon@wits.ac.za.ORCID http://orcid.org/0000-0001-6867-2119

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enzymatic reductions catalyzed by reductases generally depend on reduced nicotinamide cofactors as a hydride source. However, for industrial viability, it is more cost-effective to use water as the hydrogen source, bypassing the requirement for the cofactor. Here we report a hybrid photo-biocatalyst system based on infrared (IR) light and responsive reductive graphene quantum dots (rGQDs), for performing the direct transfer of hydrogen from water to prochiral substrates. The photo-biocatalyst, assembled from rGQDs and cross-linked aldo-keto reductase (AKR), mediates the synthesis of the pharmaceutical intermediate, (R)-1-[3,5-bis(trifluoromethyl)-phenyl] ethanol ((R)-3,5-BTPE), in 82% yield and >99.99% ee under IR illumination. Our photo-enzymatic systems can also be effectively used to drive the enzymatic reduction of imines and alkenes. Since the hybrid photo-biocatalysts are insoluble, they can be readily recovered and recycled. This work opens new avenues to create artificial photo-biocatalyst systems, enabling the facile coupling of renewable solar energy and sustainable chemical production.

Indexed as

EnzymesGraphiteQuantum DotsAldo-Keto ReductasesHydrogenInfrared RaysOxidation-ReductionPhenylethyl AlcoholPhotochemical ProcessesWater1-(3,5-bis(trifluoromethyl)phenyl)ethanolAldo-Keto ReductasesEnzymesGraphiteHydrogenPhenylethyl AlcoholWater

Identifiers

PMID40962842
PMCPMC12443980

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.