ArticleCommunications medicine2025
Shared neurobiological changes in individuals with Crohn's disease and major depressive disorder.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Mechanism-Driven Translation of Electroacupuncture for Depression: Bridging the Gap Between Preclinical and Clinical Research.Neuropsychiatric disease and treatment · 2026Review
- Aberrant Nodal Topological Properties and Functional Connectivity of Amygdala Subregions Underlie Emotion-Visceral Integration Impairment in IBS With Depressive Symptoms.Neural plasticity · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundEmerging evidence highlights the profound impact of the central nervous system on the gut. This is particularly evident in inflammatory bowel disease, where psychological stress has been shown to modulate the inflammatory response and precede disease flares. The neuropsychological correlates of the brain's involvement in Crohn's disease (CD), as well as its overlapping neurobiological pathways with major depressive disorder (MDD), remain poorly defined. This study aims to delineate these shared mechanisms using ultra-high-field neuroimaging.
methodsResting-state functional magnetic resonance imaging was conducted on 13 CD patients (age range: 20-41 years; 9 males), 13 age-matched MDD patients (20-42 years; 9 males), and 13 healthy controls (HC) (19-42 years; 9 males) using a 7 Tesla MR scanner. Assessments for symptom severity included the Beck Depression Inventory-II (BDI-II) for depression and the Gastrointestinal Symptom Rating Scale (GSRS) for CD.
resultsSignificant differences in BDI-II scores are observed among the groups (χ
conclusionsThese exploratory findings reveal similar abnormalities in brain activity and connectivity in CD and MDD. A deeper understanding of these interactions may enable integrated treatment approaches that address both psychological and physiological aspects of these interconnected conditions.
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Registered trials
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