Evidence map›Paper›PMID 40962833›Full record

ArticleScientific reports2025

Prevalence and risk factors of viral hepatitis and HIV among people experiencing homelessness in Germany based on a nationwide study.

Fabian Heinrich, Tsz Lun Ernest Wong, Wiebke Graf, Katharina Dost, Anna Brennecke, Veronika Kowalski, Victoria van Rüth, Stefanie Iwersen-Bergmann, André Hajek, Hans-Helmut König and 10 more

Abstract readMulticenter Study
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Fabian HeinrichInstitute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. fa.heinrich@uke.de.
Tsz Lun Ernest WongSection of Ophthalmology, Twin Research and Genetic Epidemiology, King's College London, London, UK. tsz_lun_ernest.wong@kcl.ac.uk.
Wiebke GrafInstitute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Katharina DostInstitute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anna BrenneckeInstitute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Veronika KowalskiInstitute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Victoria van RüthInstitute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefanie Iwersen-BergmannInstitute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
André HajekDepartment of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hans-Helmut KönigDepartment of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thomas RennéInstitute of Clinical Chemistry and Laboratory Medicine, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.
Thomas T BrehmI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Susanne PfefferleInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center, Hamburg-Eppendorf, Germany.
Julian Schulze Zur WieschI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Maura DandriI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Martin AepfelbacherInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center, Hamburg-Eppendorf, Germany.
Klaus PüschelInstitute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Benjamin OndruschkaInstitute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marc LütgehetmannInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center, Hamburg-Eppendorf, Germany. mluetgehetmann@uke.de.
Franziska StallbaumI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People experiencing homelessness (PEH) are at risk of contracting and transmitting infectious diseases. Data on PEH blood-transmitted virus prevalence and vaccination coverage is needed to design targeted interventions. A nationwide multicentre cross-sectional study of PEH was conducted. Clinical data were collected through questionnaire-based interviews, and blood samples were tested by serology and qPCR. Latent class analysis (LCA) identified subgroups of PEH, while univariable regressions identified risk factors of viral hepatitis. 643 PEH from four metropolitan areas in Germany were included. LCA revealed national short-term, long-term and international short-term PEH subgroups. The prevalence of anti-HAV-IgG, anti-HBc, anti-HBsAg, anti-HCV, anti-HEV and anti-HIV was 44% (95%CI: 39-48%), 17% (95%CI: 14-21%), 25% (95%CI: 21-29%), 18% (95%CI: 15-22%), 29% (95%CI: 25-33%) and 0.7% (95%CI: 0.2-1.7%), respectively. Active HBV and HCV infection was detected in 1.4% (95%CI: 0.7-2.7%) and 12% (95%CI: 9.6-14%), respectively. Univariable logistic regression revealed PEH with former imprisonment had 13.24 times the odds of active or past HCV infection (95%CI: 6.28-27.90) that individuals without had. This study shows the high acquisition and transmission risks for HCV/HIV among PEH. Low vaccination coverage for HAV/HBV calls for revising vaccine recommendations. High HCV infection risk associated with imprisonment highlights the need to address health disparities faced by incarcerated individuals.

Indexed as

Hepatitis, Viral, HumanHIV InfectionsIll-Housed PersonsAdultCross-Sectional StudiesFemaleGermanyHepatitis CHumansMaleMiddle AgedPrevalenceRisk FactorsYoung AdultHomelessIncarcerationInfectious diseasesVaccinationViral hepatitis

Identifiers

PMID40962833
PMCPMC12443954

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.