Evidence map›Paper›PMID 40962830›Full record

ArticleMolecular psychiatry2026

Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study.

Lani Cupo, Haley A Vecchiarelli, Daniel Gallino, Jared VanderZwaag, Katerina Bradshaw, Annie Phan, Mohammadparsa Khakpour, Benneth Ben-Azu, Elisa Guma, Jérémie P Fouquet and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lani CupoMcGill University, Department of Psychiatry, Montréal, QC, Canada. lani.cupo@mail.mcgill.ca.ORCID 0000-0001-5015-0574
Haley A VecchiarelliSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, BC, Canada.ORCID 0000-0001-6331-6107
Daniel GallinoComputational Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Research Centre, Verdun, QC, Canada.
Jared VanderZwaagSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, BC, Canada.ORCID 0000-0002-1546-0304
Katerina BradshawComputational Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Research Centre, Verdun, QC, Canada.
Annie PhanMcGill University, Department of Psychiatry, Montréal, QC, Canada.
Mohammadparsa KhakpourSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, BC, Canada.
Benneth Ben-AzuSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, BC, Canada.
Elisa GumaDepartment of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA.
Jérémie P FouquetCerebral Imaging Centre, Douglas Research Centre, Verdun, QC, Canada.ORCID 0000-0001-6815-7037
Shoshana SpringMouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-8803-5552
Brian J NiemanMouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada.
Gabriel A DevenyiMcGill University, Department of Psychiatry, Montréal, QC, Canada.ORCID 0000-0002-7766-1187
Marie-Eve TremblaySchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, BC, Canada.ORCID 0000-0003-2863-9626
M Mallar ChakravartyMcGill University, Department of Psychiatry, Montréal, QC, Canada.ORCID 0000-0002-0759-5508

Funding

Canada Foundation for Innovation (Fondation canadienne pour l'innovation) 39965
6 · The paper itself

Abstract

While cannabis use during pregnancy is often perceived as harmless, little is known about its consequences on offspring neurodevelopment. There is an urgent need to map the effects of prenatal cannabis exposure on the brain through the course of the lifespan. We used magnetic resonance imaging spanning nine timepoints, behavioral assays, and electron microscopy to build a trajectory from gestation to adulthood in mice exposed prenatally to delta-9-tetrahydrocannabinol (THC). Our results demonstrate a spatio-temporal patterning, with ventriculomegaly in THC-exposed embryos followed by a deceleration of brain growth in neonates that is sustained until adulthood, especially in females. We observed consistently impacted regions in both the cortex and subcortex, aligned with sex-dependent changes to social behavior in neonates and increased anxiety-like behavior in adolescents. Our results suggest prenatal THC exposure has a sustained sex-dependent impact on neurodevelopment that may persist into early adulthood.

Indexed as

BrainDronabinolPrenatal Exposure Delayed EffectsAnimalsAnxietyBehavior, AnimalFemaleMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLPregnancySocial BehaviorDronabinol

Identifiers

PMID40962830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.