Evidence map›Paper›PMID 40962823›Full record

ReviewJournal of perinatology : official journal of the California Perinatal Association2025

Ketogenic diet in neonates: effects, pitfalls, and a paradigm from a preterm newborn affected by pyruvate dehydrogenase deficiency.

Sokratis Katsoudas, Luis A Umana, Rebekah Clarke, Jennifer Thomas, Michelle Machie, Dimitrios Angelis

Abstract readReview
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In one paragraph

Review in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sokratis KatsoudasDepartment of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.ORCID http://orcid.org/0009-0001-4184-992X
Luis A UmanaDepartment of Pediatrics, Division of Genetics and Metabolism, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-3506-4640
Rebekah ClarkeDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jennifer ThomasDepartment of Pediatrics, Division of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Michelle MachieDepartment of Pediatrics, Division of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dimitrios AngelisDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. dimitrios.angelis@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-1071-1960

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of ketogenic diet (KD) in newborns is rare and mainly reserved for specific metabolic and seizure disorders. Furthermore, only case reports describe the effects of KD in premature infants. Here, we summarize the recent advances, indications, mechanisms of action and practical issues related to KD. We also provide a paradigm of a preterm male infant born at 34 weeks with pyruvate dehydrogenase deficiency, highlighting the therapeutic challenges and outcomes with the KD. This report underscores the complexities of managing metabolic disorders in neonates and the effects of KD.

Identifiers

PMID40962823

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.