Evidence map›Paper›PMID 40962559›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Visual Distortions in Human Amblyopia Are Correlated with Deficits in Contrast Sensitivity.

Farzaneh Olianezhad, Jianzhong Jin, Sohrab Najafian, Akihito Maruya, Qasim Zaidi, Jose-Manuel Alonso

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Farzaneh OlianezhadDepartment of Biological and Visual Sciences, SUNY Optometry, New York, New York 10036.
Jianzhong JinDepartment of Biological and Visual Sciences, SUNY Optometry, New York, New York 10036.
Sohrab NajafianDepartment of Biological and Visual Sciences, SUNY Optometry, New York, New York 10036.
Akihito MaruyaDepartment of Biological and Visual Sciences, SUNY Optometry, New York, New York 10036.
Qasim ZaidiDepartment of Biological and Visual Sciences, SUNY Optometry, New York, New York 10036.ORCID 0000-0002-1300-2879
Jose-Manuel AlonsoDepartment of Biological and Visual Sciences, SUNY Optometry, New York, New York 10036 jalonso@sunyopt.edu.ORCID 0000-0002-8066-8080

Funding

STUDIES OF THE VISUAL SYSTEMR01EY005253 · NEI · UNIVERSITY OF CONNECTICUT STORRS · PI ALONSO, JOSE MANUEL · 1985 to 2025
$9.6M
Orientation Processing Deficits in Amblyopia: Neural Bases to Functional ImplicationsR21EY035085 · NEI · STATE COLLEGE OF OPTOMETRY · PI ZAIDI, QASIM · 2023 to 2024
$450k
Shape Distortions seen by Amblyopic Children: Pereceptograms and Neural ModelsR21EY035838 · NEI · STATE COLLEGE OF OPTOMETRY · PI ZAIDI, QASIM · 2024 to 2025
$450k
NEI NIH HHS R01 EY005253NEI NIH HHS R21 EY035085NEI NIH HHS R21 EY035838
6 · The paper itself

Abstract

Amblyopia (lazy eye) is a developmental disorder of the visual cortex that causes deficits in visual acuity and shape perception. The loss of visual acuity is thought to originate from weakened cortical responses to stimuli. Here, we provide evidence for a similar mechanism to explain distortions in shape perception. We introduce a computational model that simulates perceptual distortions of grating patterns drawn by humans with amblyopia (Barrett et al., 2003). The model simulates a large variety of distortions by performing a weighted sum of rectified sinusoidal gratings (average, 3.3 gratings ∼6 times larger than foveal receptive fields in the primary visual cortex) with different dark/light duty cycles. The simulations accurately reproduce self-reported perceptions of amblyopic patients and decrease drawing-percept differences when ideal percepts (stimuli) are replaced with simulated percepts (9.03 ± 12.37%;

Indexed as

AmblyopiaContrast SensitivityAdultComputer SimulationFemaleHumansMaleModels, NeurologicalPhotic StimulationVisual Cortexcomputational modelingdevelopmental disorderLGNshape perceptionvisual cortex

Identifiers

PMID40962559
PMCPMC12590119

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.