Evidence map›Paper›PMID 40962521›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

[The causal association between circulating zinc, magnesium, and other minerals with autism spectrum disorder: a Mendelian randomization study].

Bing-Quan Zhu, Sai-Jing Chen, Tian-Miao Gu, Si-Run Jin, Dan Yao, Shuang-Shuang Zheng, Jie Shao

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Bing-Quan ZhuDepartment of Child Health Care, Children's Hospital of Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310003, China.
Sai-Jing ChenDepartment of Child Health Care, Children's Hospital of Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310003, China.
Tian-Miao GuDepartment of Child Health Care, Children's Hospital of Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310003, China.
Si-Run JinDepartment of Child Health Care, Children's Hospital of Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310003, China.
Dan YaoDepartment of Child Health Care, Children's Hospital of Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310003, China.
Shuang-Shuang ZhengDepartment of Child Health Care, Children's Hospital of Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310003, China.
Jie ShaoDepartment of Child Health Care, Children's Hospital of Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the causal association between circulating levels of zinc, magnesium, and other minerals and autism spectrum disorder (ASD).

methodsA two-sample Mendelian randomization (MR) analysis was performed using summary statistics from large-scale genome-wide association studies of European populations, including 18 382 ASD cases and 27 969 controls. Genetic data for iron, calcium, and magnesium were obtained from the UK Biobank, and data for zinc and selenium were sourced from an Australian-British cohort. A total of 351 genetic instrumental variables were selected. Causal inference was performed using inverse-variance weighting as the primary analysis method. Sensitivity analyses were performed by Cochran's

resultsNo statistically significant causal effect was observed for circulating zinc, magnesium, calcium, selenium, or iron levels on ASD risk (all

conclusionsThis study did not find significant evidence supporting a causal association between circulating zinc, magnesium, calcium, selenium, or iron levels and ASD risk, providing important clues for the etiology of ASD and precision nutritional interventions.

Indexed as

Autism Spectrum DisorderMagnesiumMendelian Randomization AnalysisMineralsZincGenome-Wide Association StudyHumansSeleniumMagnesiumMineralsSeleniumZincAutism spectrum disorderCausal associationChildMagnesiumMendelian randomizationZinc

Identifiers

PMID40962521
PMCPMC12447944

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.