Evidence map›Paper›PMID 40962516›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

[Dynamic changes in serum microRNA-15b and vascular endothelial growth factor in preterm infants with bronchopulmonary dysplasia and their value in assessing neurodevelopment].

Qian Chen, Pei-Pei Zhang, Qing-Hua Lu, Zhen-Xia Wan, Lei Huang

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Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Qian ChenDepartment of Neonatology, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China.
Pei-Pei ZhangDepartment of Neonatology, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China.
Qing-Hua LuDepartment of Neonatology, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China.
Zhen-Xia WanDepartment of Neonatology, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China.
Lei HuangDepartment of Neonatology, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the dynamic changes in serum microRNA-15b (miR-15b) and vascular endothelial growth factor (VEGF) in preterm infants with mild or moderate-to-severe bronchopulmonary dysplasia (BPD), as well as their value in assessing short-term neurodevelopment.

methodsA retrospective analysis was conducted on the medical data of 156 preterm infants with BPD who were admitted to the neonatal intensive care unit from January 2020 to February 2023. According to the severity of BPD, they were divided into a mild group (

resultsIn the mild group, there was a significant reduction in the serum level of miR-15b and a significant increase in VEGF over time (

conclusionsThere are different changing trends in serum levels of miR-15b and VEGF in preterm infants with mild and moderate-to-severe BPD. miR-15b primarily influences neurodevelopment through VEGF.

Indexed as

Bronchopulmonary DysplasiaChild DevelopmentMicroRNAsNervous SystemVascular Endothelial Growth Factor AFemaleHumansInfant, NewbornInfant, PrematureMaleRetrospective StudiesMicroRNAsMIRN15 microRNA, humanVascular Endothelial Growth Factor AVEGFA protein, humanBronchopulmonary dysplasiamicroRNA-15bNeurodevelopmentPreterm infantVascular endothelial growth factor

Identifiers

PMID40962516
PMCPMC12447931

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.