Evidence map›Paper›PMID 40962342›Full record

ArticleBMJ open2025

Study protocol for the HONIVAH trial: a single-centre randomised study assessing high-flow oxygen therapy versus non-invasive ventilation on lung volumes and the upper airway

Clément Monet, Lauranne Piron, Marine Pressac, Nicolas Molinari, Audrey De Jong, Boris Guiu, Samir Jaber

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05643911 (Effects of High-flow Oxygen Therapy and Non-invasive Ventilation on Lung Volumes and on Upper Airway in Hypoxemic Critical Care Patients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05643911 naunknown statusnot on this map

Effects of High-flow Oxygen Therapy and Non-invasive Ventilation on Lung Volumes and on Upper Airway in Hypoxemic Critical Care Patients: a Physiological Randomized Controlled Trial

TypeinterventionalSponsorUniversity Hospital, MontpellierRan2023 to 2025Enrolled56ConditionsRespiratory FailureArmsHFNC, NIV
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Clément MonetDepartment of Anaesthesiology and Critical Care Medicine, Saint Eloi University Hospital, CHU de Montpellier, Montpellier, 34000, France.ORCID http://orcid.org/0000-0001-9884-6562
Lauranne PironDepartment of Radiology, Saint Eloi University Hospital, CHU de Montpellier, Montpellier, Occitanie, France.
Marine PressacDepartment of Anaesthesiology and Critical Care Medicine, Saint Eloi University Hospital, CHU de Montpellier, Montpellier, 34000, France.
Nicolas MolinariDepartment of Statistics, Lapeyronie Hospital, University of Montpellier, Montpellier, Occitanie, France.
Audrey De JongDepartment of Anaesthesiology and Critical Care Medicine, Saint Eloi University Hospital, CHU de Montpellier, Montpellier, 34000, France.
Boris GuiuDepartment of Radiology, Saint Eloi University Hospital, CHU de Montpellier, Montpellier, Occitanie, France.
Samir JaberDepartment of Anaesthesiology and Critical Care Medicine, Saint Eloi University Hospital, CHU de Montpellier, Montpellier, 34000, France s-jaber@chu-montpellier.fr.ORCID http://orcid.org/0000-0002-7257-8069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn non-intubated patients, symptomatic treatment of hypoxaemic respiratory failure is still debated, with different options: (1) standard oxygen therapy (SOT), (2) high-flow nasal cannula oxygen therapy (HFNC) and (3) non-invasive ventilation (NIV). The objective of this study is to compare the effects of HFNC and NIV on lung volumes assessed by CT scan to allow a better understanding of their effectiveness. METHODS AND ANALYSIS: The HONIVAH study ( ETHICS AND DISSEMINATION: The study project has been approved by the appropriate ethics committee (Comité de Protection des Personnes Sud-Ouest et Outre-mer 1, France, 2022-A02458-35). Informed consent is required. The results will be submitted for publication in a peer-reviewed journal and presented at one or more scientific conferences.

trial registrationClinicalTrials.gov identifier: NCT05643911.

Indexed as

HypoxiaLungNoninvasive VentilationOxygen Inhalation TherapyRespiratory InsufficiencyCannulaCritical IllnessHumansLung Volume MeasurementsMaleProspective StudiesRandomized Controlled Trials as TopicTomography, X-Ray ComputedCLINICAL PHYSIOLOGYClinical ProtocolsHypoxiaINTENSIVE & CRITICAL CARE

Identifiers

PMID40962342
PMCPMC12443169

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.