Evidence map›Paper›PMID 40962271›Full record

ArticleAorta (Stamford, Conn.)2025

Impact of Cooling Strategies on Transfusion Requirements in Aortic Hemiarch Surgery.

Anthony V Norman, Sanjana Challa, Genevieve Lyons, Alexander M Wisniewski, Raymond J Strobel, Michael Mazzeffi, Mark Joseph, Daniel Tang, Ramesh Singh, Michael C Kontos and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aorta (Stamford, Conn.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anthony V NormanDivision of Cardiothoracic Surgery, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-5660-321X
Sanjana ChallaDivision of Cardiothoracic Surgery, University of Virginia, Charlottesville, Virginia.
Genevieve LyonsDepartment of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Alexander M WisniewskiDivision of Cardiothoracic Surgery, University of Virginia, Charlottesville, Virginia.
Raymond J StrobelDivision of Cardiothoracic Surgery, University of Virginia, Charlottesville, Virginia.
Michael MazzeffiDepartment of Anesthesia, University of Virginia, Charlottesville, Virginia.
Mark JosephDepartment of Cardiothoracic Surgery, Carilion Clinic, Roanoke, Virginia.
Daniel TangDepartment of Cardiothoracic Surgery, INOVA Heart and Vascular Institute, Falls Church, Virginia.
Ramesh SinghDepartment of Cardiothoracic Surgery, INOVA Heart and Vascular Institute, Falls Church, Virginia.
Michael C KontosDepartment of Cardiac Surgery, Virginia Commonwealth University, Richmond, Virginia.
Mohammed QuaderDepartment of Cardiac Surgery, Virginia Commonwealth University, Richmond, Virginia.
Kenan YountDivision of Cardiothoracic Surgery, University of Virginia, Charlottesville, Virginia.
Nicholas R TemanDivision of Cardiothoracic Surgery, University of Colorado School of Medicine, Aurora, Colorado.
Ourania PreventzaDivision of Cardiothoracic Surgery, University of Virginia, Charlottesville, Virginia.
Jared P BellerDivision of Cardiothoracic Surgery, University of Virginia, Charlottesville, Virginia.

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Cardiovascular Surgery Training ProgramT32HL007849 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRON, IRVING L., LAUBACH, VICTOR E · 1998 to 2025
$7.0M
Institutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI PAPIN, JASON, WORRALL, BRADFORD B · 2019 to 2023
$3.9M
National Center for Advancing Translational Science of the National Institutes of Health Award UL1TR003015/KL2TR003016National Heart Lung and Blood Institute/National Institute of Health T32HL007849NCATS NIH HHS KL2 TR003016NCATS NIH HHS UL1 TR003015NHLBI NIH HHS T32 HL007849
6 · The paper itself

Abstract

Deep hypothermic circulatory arrest (DHCA) is associated with coagulopathy but facilitates aortic arch surgery. Conflicting data suggest moderate hypothermic circulatory arrest (MHCA) may reduce transfusion requirements. We hypothesized MHCA would reduce transfusion requirements.We studied patients undergoing aortic hemiarch surgery for nondissected, aneurysmal disease from July 2014 to May 2023 utilizing a multicenter collaborative. Patients were stratified by DHCA (14.1-20°C) and MHCA (20.1-28°C). Packed red blood cells (pRBC), fresh frozen plasma (FFP), cryoprecipitate, and platelet transfusion requirements were assessed. A negative binomial model accounting for hospital random effect was fitted to identify risk factors for increased transfusion requirements.Of the 451 patients undergoing hemiarch surgery, 373 (83%) had MHCA and 78 (17%) had DHCA. MHCA patients had shorter cardiopulmonary bypass (135 minutes [105, 182] vs. 216 minutes [183, 263],

Identifiers

PMID40962271
PMCPMC12472810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.