ArticleOsteoarthritis and cartilage2025
Microstructure and matrix-filled lacunae impact mechanical response of temporomandibular joint cartilage under physiological loading.
Article in Osteoarthritis and cartilage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Click Chemistry-Based Quantification of Extracellular Matrix Turnover for Drug Screening and Regenerative Medicine.Annals of biomedical engineering · 2026Article
- Increased angiogenesis-osteogenesis coupling in the endplate at early stages of intervertebral disc degeneration.Scientific reports · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo compare cell morphology, extracellular matrix (ECM) composition, microstructure, and mechanical response to dynamic physiological loading between knee and temporomandibular joint (TMJ) condylar cartilage to better understand the unique fibro-hyaline bilayer structure of TMJ condylar cartilage.
methodsCartilage samples were harvested from the femoral and TMJ condyles of the same pigs. Cell morphology was quantified using confocal imaging and 3D image analysis. Total extracellular matrix (ECM) composition was assessed histologically, and the spatial distribution and synthesis rates of nascent glycosaminoglycans and collagen were measured using a new click chemistry technique. Mechanical properties and phase lag were evaluated across a range of loading magnitudes and frequencies to simulate physiological dynamic loading conditions.
resultsTMJ condylar cartilage exhibited a distinct hyaline microstructure compared to knee cartilage, including higher cell density (3.6 [3.1 4.2] vs 1.7 [1.3 2.2] · 10
conclusionsTMJ condylar cartilage displays a distinct hyaline microstructure characterized by matrix-filled lacunae, high cell density, and narrow collagen-rich interterritorial spaces. These features underlie its ability to remain compliant under low stress and stiffen under high stress, supporting its load-dependent mechanical function when speaking and chewing.
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Registered trials
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