Evidence map›Paper›PMID 40961922›Full record

ArticleCell reports. Medicine2025

Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity.

Rou Zhao, Baoyu He, Lunhua Huang, Yanli Wu, Ting Liu, Jilan Liu, Mingsheng Zhao, Tao Zhong, Yanhua Zhang, Xiao Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rou ZhaoKey Laboratory of Cell and Biomedical Technology of Shandong Province, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China; Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China; Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China.
Baoyu HeKey Laboratory of Cell and Biomedical Technology of Shandong Province, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China; Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China.
Lunhua HuangDepartment of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China.
Yanli WuDepartment of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China.
Ting LiuDepartment of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China.
Jilan LiuKey Laboratory of Cell and Biomedical Technology of Shandong Province, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China; Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China.
Mingsheng ZhaoKey Laboratory of Cell and Biomedical Technology of Shandong Province, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China; Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, China.
Tao ZhongKey Laboratory of Cell and Biomedical Technology of Shandong Province, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China; Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, China.
Yanhua ZhangShanghai Cancer Center, Fudan University, Shanghai 200032, China.
Xiao ZhangDepartment of Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200032, China.
Huabao XiongKey Laboratory of Cell and Biomedical Technology of Shandong Province, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China; Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, China. Electronic address: xionghbl@163.com.
Bin ZhangKey Laboratory of Cell and Biomedical Technology of Shandong Province, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China; Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China. Electronic address: zhangbin@mail.jnmc.edu.cn.
Qingli BieKey Laboratory of Cell and Biomedical Technology of Shandong Province, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China; Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, China. Electronic address: xiaobie890101@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cells exhibit impaired anti-tumor activity upon entering the tumor microenvironment (TME); however, the precise mechanism(s) remains elusive. In this study, we demonstrate that AQP5

Indexed as

Aquaporin 5ArginineKiller Cells, NaturalNeoplastic Stem CellsStomach NeoplasmsAnimalsCell Line, TumorHumansMiceTumor MicroenvironmentUreaAQP5 protein, humanAquaporin 5ArginineUreaAQP5cancer stem cellNK cellTCA cycleurea cycle

Identifiers

PMID40961922
PMCPMC12490235

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.