Evidence map›Paper›PMID 40961740›Full record

ReviewJournal of inorganic biochemistry2026

Key roles of GAPDH, Hsp90, and NO in heme trafficking.

Dennis J Stuehr, Pranjal Biswas, Yue Dai, Dhanya Thamaraparambil Jayaram, Priya Das Sinha, Elizabeth A Sweeny, Arnab Ghosh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of inorganic biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dennis J StuehrDepartment of Inflammation and Immunity, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland 44195, OH, USA. Electronic address: stuehrd@ccf.org.
Pranjal BiswasDepartment of Inflammation and Immunity, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland 44195, OH, USA.
Yue DaiDepartment of Inflammation and Immunity, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland 44195, OH, USA.
Dhanya Thamaraparambil JayaramDepartment of Inflammation and Immunity, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland 44195, OH, USA.
Priya Das SinhaDepartment of Inflammation and Immunity, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland 44195, OH, USA.
Elizabeth A SweenyDepartment of Biochemistry, Medical College of Wisconsin, 53226, Milwaukee, WI, USA.
Arnab GhoshDepartment of Inflammation and Immunity, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland 44195, OH, USA.

Funding

Defining a pathway for mitochondrial heme traffickingR01GM148664 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI DENNIS J STUEHR · 2023 to 2026
$2.1M
Coordinate control of hemeprotein maturation and function by cell chaperones, heme, and nitric oxideR01GM130624 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI STUEHR, DENNIS J · 2019 to 2022
$1.9M
Nitric oxide induced soluble guanylate cyclase dysfunction or activation: Implications as a disease indicator or in therapyR01HL150049 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI GHOSH, ARNAB · 2020 to 2023
$1.7M
Heme allocation and disruptions in asthma and the failing heartK99HL144921 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI SWEENY, ELIZABETH A. · 2019 to 2020
$199k
NHLBI NIH HHS K99 HL144921NHLBI NIH HHS R01 HL150049NIGMS NIH HHS R01 GM130624NIGMS NIH HHS R01 GM148664
6 · The paper itself

Abstract

Intracellular trafficking of mitochondrial heme to create functional heme proteins presents a fundamental challenge in animal cells. This article provides some background on heme allocation, discusses some of the concepts, and then reviews research from the last two decades that has uncovered unexpected and important roles for glyceraldehyde 3-phosphate dehydrogenase (GAPDH), heat shock protein 90 (Hsp90), and nitric oxide (NO) in enabling and regulating cell heme allocations to hemeproteins that mature and function outside of the mitochondria. A model for how hemeprotein heme contents and functions in cells can be regulated through the coordinate participation of GAPDH, Hsp90, and NO is presented.

Indexed as

Glyceraldehyde-3-Phosphate DehydrogenasesHemeHSP90 Heat-Shock ProteinsNitric OxideAnimalsHumansMitochondriaProtein TransportGlyceraldehyde-3-Phosphate DehydrogenasesHemeHSP90 Heat-Shock ProteinsNitric OxideCatalysisChaperoneHemeproteinHomeostasisMitochondriaNitric oxideNitrosation

Identifiers

PMID40961740
PMCPMC13292358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.