Evidence map›Paper›PMID 40961519›Full record

ArticleJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)2025

Hexavalent chromium exposure impacts the metabolome of human lung fibroblast cells.

James T F Wise, Davide Chiarugi, Jinhua Chi, John Pierce Wise

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Article in Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

James T F WiseWise Laboratory of Nutritional Toxicology and Metabolism, Department of Human Nutrition, Food and Animal Sciences, College of Tropical Agriculture and Human Resilience, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA; School of Nutrition and Food Sciences, College of Agriculture, Louisiana State University, Baton Rouge, LA 70803, USA; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40292, USA. Electronic address: jw410@hawaii.edu.
Davide ChiarugiGeneVia Technologies, Hämeenkatu 14C, Tampere 33100, Finland.
Jinhua ChiCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
John Pierce WiseWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40292, USA.

Funding

Chromosome Instability Drives Metal-Induced Lung CancerR35ES032876 · NIEHS · UNIVERSITY OF LOUISVILLE · PI John Pierce Wise · 2021 to 2026
$6.1M
NIEHS NIH HHS R35 ES032876
6 · The paper itself

Abstract

introductionLung cancer is the number one cause of cancer death and survival rates have not significantly improved for decades. The underlying mechanism of lung cancer remains elusive, but it is known chromosome instability, altered DNA, and dysregulated cellular energetics are key to cancers. However, the importance of energetics during chemical carcinogenesis is unexplored.

methodsWe exposed human lung cells to hexavalent chromium [Cr(VI)], a known human respiratory carcinogen, for 24 or 120 h. Then, we performed untargeted metabolomics and analyzed changes with concentration and time through differential metabolomics.

resultsThere was a distinct metabolic response with increasing Cr(VI) concentrations and a difference in the metabolic response with time, where metabolic enrichment of amino acid metabolism and nucleotide metabolism were affected with time and Cr(VI) treatment.

conclusionsThis study provides the first link between energy metabolism responses and chemical carcinogenesis, providing the foundation for a more in-depth investigation into how Cr(VI) alters the metabolic response of cells to induce lung cancer. We anticipate our study will be a starting point for more in-depth investigations into the role of dysregulated cellular energetics during carcinogenesis, which will further establish these changes as a critical early-stage event in carcinogenesis.

Indexed as

ChromiumFibroblastsLungMetabolomeHumansMetabolomicsChromiumchromium hexavalent ionCancer metabolismHexavalent chromiumHuman lung cellsMetabolomeMetabolomics

Identifiers

PMID40961519
PMCPMC12500332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.