Evidence map›Paper›PMID 40961462›Full record

ArticleThe Journal of physiology2025

The influence of biological sex on the metabolic basis of skeletal muscle fatigue in vivo.

Fabio G Laginestra, Ryan M Broxterman, Danilo Iannetta, Matthew T Lewis, Jason S Kofoed, Jesse C Craig, Gregory Stoddard, Gwenael Layec, Eun-Kee Jeong, Markus Amann

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fabio G LaginestraDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-4767-7249
Ryan M BroxtermanDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-7388-2214
Danilo IannettaDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-6914-174X
Matthew T LewisDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-0580-6866
Jason S KofoedDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Jesse C CraigDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-5959-4139
Gregory StoddardDepartment of Informatics, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-6292-276X
Gwenael LayecSchool of Health and Kinesiology, University of Nebraska, Omaha, NE, USA.
Eun-Kee JeongDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Markus AmannDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-4012-8880

Funding

Role of Sensory Neurons in Human Cardiovascular DiseaseR01HL116579 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2013 to 2021
$3.4M
Autonomic Dysfunction in Patients with HFpEFR01HL162856 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2023 to 2026
$2.7M
Cardiovascular and neuromuscular issues in chronic painR01HL170007 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2024 to 2026
$2.3M
CSRD VA IK2 CX002114NHLBI NIH HHS R01 HL116579NHLBI NIH HHS R01 HL162856NHLBI NIH HHS R01 HL170007RRD VA I01 RX003343
6 · The paper itself

Abstract

This study in humans was designed to evaluate: (1) the overall relationships between muscle fatigue and inorganic phosphate (Pi) and hydrogen ions (H

Indexed as

Muscle FatigueMuscle, SkeletalQuadriceps MuscleAdultExerciseFemaleHumansHydrogenIsometric ContractionMaleMuscle ContractionPhosphatesSex CharacteristicsYoung AdultHydrogenPhosphatesmetabolic perturbationneuromuscular fatiguesex differences

Identifiers

PMID40961462
PMCPMC13570562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.