ArticleMagnetic resonance in medicine2026
Transcranial Doppler ultrasound validation of BOLD-fMRI cerebral blood flow relationship.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Gender-Related Differences in Cerebrovascular Reactivity to L-Arginine in Middle-Aged Type 1 Diabetes Patients.International journal of molecular sciences · 2026Article
- Transcranial Doppler ultrasound validation of BOLD-fMRI cerebral blood flow relationship.Magnetic resonance in medicine · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
purposeA precise understanding of the interplay between cerebral blood flow (CBF) and blood oxygen level-dependent (BOLD) fMRI signals is essential for advancing cerebrovascular research. Although calibrated BOLD approaches often rely on arterial spin labelling (ASL) to estimate CBF, alternative validation using transcranial Doppler ultrasound (TCD) has not been explored. This study aims to determine whether a simplified hemodynamic model and linear regression can accurately characterize the relationship between TCD-derived CBF velocity and BOLD-fMRI responses during a ramp CO
methodsTwenty-five healthy participants underwent two sessions. In session 1, right middle cerebral artery velocity (MCAv) was acquired using clinical TCD. In session 2, 3 T BOLD-fMRI data were collected. Both sessions used a ramp PETCO
resultsFinal analysis included 21 participants. The hemodynamic model produced consistent fits (R
conclusionBoth modeling approaches successfully linked TCD-derived MCA
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