ArticleMagnetic resonance in medicine2026
Bidirectional crusher gradient method to estimate the labeling efficiency of pseudo-continuous arterial spin labeling MRI in mice.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Bidirectional crusher gradient method to estimate the labeling efficiency of pseudo-continuous arterial spin labeling MRI in mice.Magnetic resonance in medicine · 2026Article
- Vascular smooth muscle cell loss, but not neuroinflammation, drives cerebrovascular reactivity impairment in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Vascular smooth muscle cell loss, but not neuroinflammation, drives cerebrovascular reactivity impairment in Alzheimer's disease.bioRxiv : the preprint server for biology · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeTo develop an experimental method for measuring the labeling efficiency of pseudo-continuous arterial spin labeling (pCASL) MRI in mice.
methodsWe propose a method using bidirectional crusher gradients to modulate vascular signals in the azygos pericallosal artery (azPA) of the mouse brain, applied with and without pCASL labeling. The combination of corresponding signals allows the estimation of labeling efficiency. A series of studies were conducted to optimize post-labeling delay, labeling duration, TR, and slice thickness. The sensitivity of labeling efficiency measurements to changes in the labeling scheme was examined. Finally, a physiological challenge with 5% CO
resultsUpon systematic testing, optimal acquisition parameters included a labeling duration ≥1170 ms, a TR of 3 s, and an imaging slice thickness of 0.75 mm. To quantitatively estimate labeling efficiency, the bolus arrival time to azPA was required and found to be 209.2 ± 19.1 ms. Typical labeling efficiencies in mouse pCASL scans were 0.780 ± 0.048 (mean ± SD). Furthermore, hypercapnia was found to increase pCASL labeling efficiency.
conclusionOur proposed method facilitates perfusion measurement using pCASL MRI by accounting for intersubject variations in labeling efficiency, offering great potential for applications in pathophysiological studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.