Evidence map›Paper›PMID 40961266›Full record

ArticleAmerican journal of respiratory and critical care medicine2026

A simple index for predicting mucus plugs in patients with chronic obstructive pulmonary disease.

Wei Wang, Ruchita Borgaonkar, Sofia K Mettler, Andrew Yen, Scott Grumley, Sushilkumar Sonavane, Carrie L Pistenmaa, Pietro Nardelli, Raul San José Estépar, Alejandro A Diaz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wei WangHarvard Medical School, Boston, MA, United States.
Ruchita BorgaonkarDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Sofia K MettlerHarvard Medical School, Boston, MA, United States.
Andrew YenDepartment of Radiology, University of California, San Diego, San Diego, CA, United States.
Scott GrumleyDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Sushilkumar SonavaneDepartment of Radiology, Mayo Clinic, Jacksonville, FL, United States.
Carrie L PistenmaaHarvard Medical School, Boston, MA, United States.
Pietro NardelliHarvard Medical School, Boston, MA, United States.
Raul San José EstéparHarvard Medical School, Boston, MA, United States.ORCID 0000-0002-3677-1996
Alejandro A DiazHarvard Medical School, Boston, MA, United States.ORCID 0000-0001-5037-2919

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Clinical Implications, Genomics, and Transcriptions of Mucus Plugging in SmokersR01HL149861 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., DIAZ, ALEJANDRO · 2020 to 2023
$3.2M
Understanding airway mucus dysfunction in population-based studiesR01HL164824 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2022 to 2025
$2.7M
Clinical implications and Proteomics of Bronchiectasis Progression in SmokersR01HL173017 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Alejandro Diaz, Raul San Jose Estepar · 2024 to 2026
$2.6M
Structural and Funcional Vascular Phenotyping in Smokers with Pulmonary Hypertension using Artificial IntelligenceK25HL157601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Pietro Nardelli · 2024 to 2026
$563k
AstraZenecaBoehringer-IngelheimGenentechGlaxoSmithKlineNHLBI NIH HHS K25 HL157601NHLBI NIH HHS R01 HL149861NHLBI NIH HHS R01-HL149861NHLBI NIH HHS R01 HL164824NHLBI NIH HHS R01-HL164824NHLBI NIH HHS R01 HL173017NHLBI NIH HHS R01-HL173017NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NovartisSunovion
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40961266
PMCPMC12831125

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.