Evidence map›Paper›PMID 40961238›Full record

ArticleJournal of Parkinson's disease2025

Gut microbial shifts toward inflammation in Parkinson's disease: Insights from pilot shotgun metagenomics Egyptian cohort.

Ali Shalash, Shahd Ezzeldin, Sara Hashish, Yara Salah, Noha L Dawood, Ahmed Moustafa, Mohamed Salama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ali ShalashDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Shahd EzzeldinInstitute of Global Health and Human Ecology, The American University in Cairo, New Cairo City, Egypt.
Sara HashishInstitute of Global Health and Human Ecology, The American University in Cairo, New Cairo City, Egypt.
Yara SalahDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Noha L DawoodInstitute of Global Health and Human Ecology, The American University in Cairo, New Cairo City, Egypt.
Ahmed MoustafaInstitute of Global Health and Human Ecology, The American University in Cairo, New Cairo City, Egypt.
Mohamed SalamaInstitute of Global Health and Human Ecology, The American University in Cairo, New Cairo City, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiome alterations are increasingly linked to Parkinson's disease (PD), yet regional signatures remain underexplored. We performed shotgun metagenomic sequencing of stool samples from Egyptian PD patients and healthy controls. PD patients exhibited depletion of short-chain fatty acid-producing taxa, and enrichment of pathobionts. Our findings suggested a pro-inflammatory gut shift in PD and emphasized the need for geographically diverse microbiome studies. While limited in sample size (n = 7 PD patients and n = 6 controls), this pilot addressed a critical gap in African PD microbiome research.

Indexed as

DysbiosisGastrointestinal MicrobiomeInflammationParkinson DiseaseAgedCohort StudiesEgyptFecesFemaleHumansMaleMetagenomicsMiddle AgedPilot ProjectsEgyptian cohortgut microbiomemicrobial diversityParkinson's diseaseshotgun metagenomics

Identifiers

PMID40961238
PMCPMC13347530

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.