ArticleScience advances2025
Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A single-nuclei multiomics resource across four brain regions prioritises human neural cell types influencing brain-related traits.bioRxiv : the preprint server for biology · 2026Article
- The Baboon as a Model to Study Human Health and Complex Disease.American journal of primatology · 2026Review
- Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala.Addiction biology · 2026Article
- Local control of dopamine release in nucleus accumbens gates opioid withdrawal aversion.bioRxiv : the preprint server for biology · 2026Article
- Prenatal maternal immune activation triggers lasting cell-specific transcriptomic dysregulation in the amygdala of primate offspring.Molecular psychiatry · 2026Article
- Transcriptional response to chronic long-access fentanyl self-administration in rat habenula and amygdala.bioRxiv : the preprint server for biology · 2025Article
- Integrating Aversive Memories in the Basolateral Amygdala.Biological psychiatry · 2025Review
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19 authors.
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Abstract
The amygdaloid complex mediates learning, memory, and emotions. Understanding cellular and anatomical features specialized in the primate amygdala versus other mammals requires a systematic, anatomically resolved molecular analysis of neuron types. We analyzed five nuclear subdivisions of the primate amygdala with single-nucleus RNA sequencing in macaques, baboons, and humans to examine gene expression profiles for excitatory and inhibitory neurons. Integrated analyses across species identified diverse subtypes of glutamatergic and GABAergic neurons that are highly conserved across primates. Compositional analyses revealed that subdivisions of the primate basolateral complex contain distinct classes of glutamatergic neurons and divergent gene expression profiles for parvalbumin and somatostatin GABAergic neurons. Referencing primate neuron types to transcriptomic atlases of the murine amygdala highlighted primate-specific specializations for glutamatergic neurons and identified which neuron types are conserved across mammals and amygdalar subdivisions. Understanding the molecular heterogeneity of anatomically resolved amygdalar neuron types provides a cellular framework for improving models of how amygdalar circuits contribute to cognition and mental health.
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