Evidence map›Paper›PMID 40961167›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Hearing loss, plasma neurodegenerative biomarkers, and cognitive function: Independent and additive effects.

Semere Bekena, Ramkrishna K Singh, Yiqi Zhu, Carlos Cruchaga, Steven E Arnold, Beau M Ances, Ganesh M Babulal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Semere BekenaDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0009-0008-6514-0502
Ramkrishna K SinghDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-9022-2317
Yiqi ZhuDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-3400-589X
Carlos CruchagaDepartment of Psychiatry, Washington University, St. Louis, MO, USA.ORCID 0000-0002-0276-2899
Steven E ArnoldDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9487-415X
Beau M AncesDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-3862-7397
Ganesh M BabulalDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-7966-3509

Funding

VULNERABILITY AND RESILIENCY IN THE AGING ADULT BRAIN CONNECTOME (AABC)U19AG073585 · NIA · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2021 to 2026
$41.3M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Naturalistic driving as a functional neurobehavioral marker of preclinical and symptomatic Alzheimer diseaseR01AG068183 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2020 to 2024
$6.7M
The Impact of Depression and Preclinical Alzheimer Disease on Driving Among Older AdultsR01AG067428 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2020 to 2024
$4.0M
Aging Research Characterizing Health Exposome via Social drivers (ARCHES)R01AG074302 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2021 to 2025
$3.7M
NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG067428NIA NIH HHS R01 AG068183NIA NIH HHS R01 AG074302NIA NIH HHS U19 AG073585
6 · The paper itself

Abstract

BackgroundHearing loss is one of the most prominent modifiable risk factors for dementia, accounting for one of the largest population-attributable risk among midlife exposures according to the Lancet Commission on Dementia. Plasma biomarkers such as neurofilament light (NfL), glial fibrillary acidic protein (GFAP), and phosphorylated tau-217 (Ptau

Indexed as

CognitionHearing LossAgedAged, 80 and overAgingBiomarkersCross-Sectional StudiesFemaleGlial Fibrillary Acidic ProteinHumansMaleMiddle AgedNeurofilament ProteinsNeuropsychological Teststau ProteinsBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinstau ProteinsAlzheimer's diseasecardiometabolic risk factorsglial fibrillary acidic proteinhearing lossLDL cholesterolneurodegenerationneurofilament light chainphosphorylated tau protein 217plasma biomarkersPreclinical Alzheimer’s Cognitive Composite

Identifiers

PMID40961167
PMCPMC12790462

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.