ArticlePloS one2025
Post-vaccination SARS-CoV-2 infections among healthcare workers in a tertiary hospital in Ghana.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- COVID-19 vaccine booster uptake among healthcare workers in Bangladesh: predictors, challenges, and lessons from a low-income setting.Tropical medicine and health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVaccines remain the most effective preventive measure against the ever-changing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. However, vaccine access remains unequal, leaving healthcare workers in low- and middle-income countries (LMICs) like Ghana at increased risk, despite early prioritisation. These inequities threaten both individual safety and the resilience of health systems. Moreover, SARS-CoV-2 infections continue to occur, particularly with emerging variants, compounding these risks. This study aimed to investigate the incidence and risk factors associated with post-vaccination SARS-CoV-2 infections among healthcare workers at a tertiary hospital in Ghana following the administration of the ChAdOx1nCoV-19 vaccine.
methodWe conducted a prospective cohort study of 4252 healthcare workers aged 18 and above, who tested negative for the SARS-CoV-2, and partially or fully vaccinated with the ChAdOx1nCoV-19 vaccine at baseline. After completing the baseline questionnaire, healthcare workers were followed up for one year.
results2283 out of the 4252 (53.7%) healthcare workers had post-vaccination infections, with an overall incidence of 95.7 cases per 100 person-years (95% CI: 91.8-99.7) of follow-up. The incidence of breakthrough infection was 82.0 cases per 100 person-years (95% Cl 78.0-86.0). In a multivariable Cox regression, age, vaccination status, occupation, clinical stations, frontline status and previous SARS-CoV-2 infections were significantly associated with post-vaccination infections. Compared to non-clinical healthcare workers, nurses (HR = 1.91, 95% CI: 1.69-2.17) and doctors (HR = 1.37, 95% CI: 1.24-1.73) had a higher risk of post-vaccination infections. Similarly, elderly individuals (HR = 1.04, 95% CI: 1.02-1.05) and those with comorbidities (HR = 1.86, 95% CI: 1.67-1.73) were more likely to develop post-vaccination infections. Frontline healthcare workers and healthcare workers stationed at the point-of-entry services (emergency and outpatient clinics) had a high rate of infections. However, previous SARS-CoV-2 infections (HR = 0.80, 95% CI: 0.71-0.53) and full vaccination (HR = 0.56, 95% CI: 0.51-0.62) conferred some protection, despite an overall rise in infection post vaccination incidence.
conclusionIn conclusion, the results of our study suggest a high incidence of post-vaccination infections among healthcare workers in the context of varying epidemic waves. Additionally, the study identified partial or incomplete vaccination, elderly workers, comorbidities, frontline workers, nurses and point-of-entry service roles as high-risk factors for post-vaccination infections. These findings reinforce the need for tailored booster strategies and strengthened protection for high-risk healthcare workers in LMIC settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.