Evidence map›Paper›PMID 40960917›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

The AhR Is a Critical Regulator of the Pulmonary Response to Cannabis Smoke.

Emily T Wilson, Roham Gorgani, Nicole S Heimbach, Alexandra Bartolomucci, Thupten Tsering, Julia V Burnier, David H Eidelman, Carolyn J Baglole

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The AhR Is a Critical Regulator of the Pulmonary Response to Cannabis Smoke.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emily T WilsonDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Roham GorganiResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Nicole S HeimbachDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Alexandra BartolomucciResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Thupten TseringResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Julia V BurnierResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
David H EidelmanResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Carolyn J BagloleDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.ORCID https://orcid.org/0000-0002-3107-0437

Funding

Canadian Government | Canadian Institutes of Health Research (CIHR) 162273FRQ | Fonds de Recherche du Québec-Santé (FRQS)
6 · The paper itself

Abstract

Cannabis use is prevalent worldwide, with smoking being the most common method of consumption. When smoking cannabis, users are exposed to both harmful combustion products and cannabinoids. The aryl hydrocarbon receptor (AhR), a transcription factor activated by both cannabinoids and combustion products, is known to regulate pulmonary responses to environmental insults. Therefore, we hypothesized that AhR activation would reduce susceptibility to the harmful effects of inhaled cannabis smoke. To investigate this hypothesis, Ahr

Indexed as

Basic Helix-Loop-Helix ProteinsCannabisLungMarijuana SmokingReceptors, Aryl HydrocarbonSmokeAnimalsBronchoalveolar Lavage FluidExtracellular VesiclesInflammationMaleMiceMice, Inbred C57BLMice, KnockoutProteomicsAhr protein, mouseBasic Helix-Loop-Helix ProteinsReceptors, Aryl HydrocarbonSmokearyl hydrocarbon receptorcannabisextracellular vesiclespulmonary system

Identifiers

PMID40960917
PMCPMC12442951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.