Evidence map›Paper›PMID 40960864›Full record

ArticleJournal of medical microbiology2025

Rapid deprotection and purification of ceftaroline free base from its phosphoramidate prodrug.

Souvik Roy, Robert D Kina, Nathaniel N Koloian, Daniah Zubair, Alexis A Brecht, Andrew M Lipchik, Andrew D Berti

Abstract read
In one paragraph

Article in Journal of medical microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Souvik RoyDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Robert D KinaDepartment of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Nathaniel N KoloianDepartment of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Daniah ZubairDepartment of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Alexis A BrechtDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Andrew M LipchikDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Andrew D BertiDepartment of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.

Funding

Research Enhancement for BUILDing Detroit (ReBUILDetroit)TL4GM118983 · NIGMS · UNIVERSITY OF DETROIT MERCY · PI BRYANT-FRIEDRICH, AMANDA C, SNYDER, KATHERINE E · 2015 to 2023
$17.0M
Research Enhancement for BUILDing Detroit (ReBUILDetroit)UL1GM118982 · NIGMS · UNIVERSITY OF DETROIT MERCY · PI SNYDER, KATHERINE E · 2015 to 2023
$10.8M
Research Enhancement for BUILDing Detroit (ReBUILDetroit)RL5GM118981 · NIGMS · UNIVERSITY OF DETROIT MERCY · PI BRYANT-FRIEDRICH, AMANDA C, SNYDER, KATHERINE E · 2015 to 2023
$4.8M
NIGMS NIH HHS RL5 GM118981NIGMS NIH HHS TL4 GM118983NIGMS NIH HHS UL1 GM118982
6 · The paper itself

Abstract

Contemporary pharmaceutical design often incorporates functional groups to improve the pharmacokinetic/pharmacodynamic profile of a desired active chemical entity. These compounds are known as prodrugs. While prodrug enhancements may improve a medication's clinical utility, they often limit the ability for

Indexed as

AmidesAnti-Bacterial AgentsCephalosporinsPhosphoric AcidsProdrugsCeftarolineAmidesAnti-Bacterial AgentsCeftarolineCephalosporinsphosphoramidic acidPhosphoric AcidsProdrugsceftarolinedeprotectionphosphoramidateprodrug

Identifiers

PMID40960864
PMCPMC12444786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.