Evidence map›Paper›PMID 40960728›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2025

Design and evaluation of light-responsive ruthenium complexes for neurotransmitter release: synthesis, characterization, DFT and gene regulation studies.

Naman Shah, Rhydham Karnik, Helly Shah, Ranjitsinh V Devkar, Debjani Chakraborty

Abstract read
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Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Naman ShahDepartment of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390 002, India.
Rhydham KarnikDepartment of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390 002, India.
Helly ShahDepartment of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390 002, India.
Ranjitsinh V DevkarDepartment of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390 002, India.
Debjani ChakrabortyDepartment of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390 002, India. debjani.chakraborty-chem@msubaroda.ac.in.

Funding

Gujarat State Biotechnology Mission GSBTM/JD(R&D)/610/20-21/347 dated 26-04-2021
6 · The paper itself

Abstract

Neurotransmitters are critical biomolecules involved in the mediation of synaptic transmission and the control of many neurophysiological processes. Their therapeutic potential, however, is usually limited by fast degradation, off-target action, and absence of spatial targeting. Photoactivated chemotherapy (PACT) offers a potential solution for spatially and temporally controlled delivery of bioactive molecules. In this paper, neurotransmitters were encapsulated in light-sensitive ruthenium (II) polypyridyl caged complexes, which would be inert in the dark and release upon irradiation with 465 nm blue light through photolysis. The complexes were prepared and thoroughly characterized by UV-VIS spectroscopy, FTIR, ESI-MS, NMR, CHNS elemental analysis, and ICP-MS, establishing coordination and structural integrity. Photorelease of neurotransmitters was verified by time-resolved UV-VIS and mass spectrometric investigations. To assess the biological relevance of light-induced release, gene expression analysis was conducted, demonstrating upregulation of the important neuronal markers after irradiation. The findings prove the efficiency of ruthenium-based cages in light-regulated neurotransmitter delivery and justify their possible application in neurotherapeutic PACT platforms.

Indexed as

Coordination ComplexesDensity Functional TheoryLightNeurotransmitter AgentsRutheniumGene Expression RegulationMolecular StructureCoordination ComplexesNeurotransmitter AgentsRutheniumNeurotransmittersPhotoactivationPhotolabilePhoto releaseRu (II)-polypyridyl cageRuthenium

Identifiers

PMID40960728

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.