Evidence map›Paper›PMID 40960726›Full record

ArticleJournal of neurovirology2025

The presence of human polyomavirus JC (JCPyV) in pediatric brain tumors: a plausible trigger in Wnt/β-catenin pathway.

Sara Passerini, Sara Messina, Marta De Angelis, Lucia Nencioni, Francesca Gianno, Manila Antonelli, Valeria Pietropaolo

Erratum issuedAbstract read
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In one paragraph

Article in Journal of neurovirology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sara PasseriniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, 00185, Italy. sara.passerini@uniroma1.it.
Sara MessinaDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, 00185, Italy.
Marta De AngelisDepartment of Public Health and Infectious Diseases, Sapienza University, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.
Lucia NencioniDepartment of Public Health and Infectious Diseases, Sapienza University, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.
Francesca GiannoDepartment of Radiological, Oncological and Anatomo‑Pathological Sciences, "Sapienza" University of Rome, Rome, Italy.
Manila Antonelli *Department of Radiological, Oncological and Anatomo‑Pathological Sciences, "Sapienza" University of Rome, Rome, Italy.
Valeria Pietropaolo *Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, 00185, Italy. valeria.pietropaolo@uniroma1.it.

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca AR124190258C1281
6 · The paper itself

Abstract

JC polyomavirus (JCPyV) is associated with progressive multifocal leukoencephalopathy (PML), but its plausible role in brain cancers is also disputed. One candidate to mediate cell transformation is the Large T antigen (LTAg), which has the capability to bind the Wnt pathway protein β-catenin, thus deregulating the cell cycle. In the current study, we investigated the presence and molecular state of JCPyV in pediatric brain tumors and the effects of virus-positivity on the Wnt pathway. JCPyV DNA was found in 31/101 (30.7%) brain tumors with a viral load of 3.2 copies/cell. The amplified NCCR revealed an archetype sequence, and VP1 reported a high degree of homology with the reference strain. The LTAg gene was reported in all JCPyV-positive tumors. Interestingly, among them, 5 tissues did not express VP1 and viral miRNAs, supporting a hampering of late region transcription. Over-expression of β-catenin, c-myc and cyclin D1 was observed in JCPyV-positive tissues compared to negative ones, suggesting that the virus may exploit this signaling pathway, potentially contributing to brain carcinogenesis. The current study adds further evidence of JCPyV prevalence in human brain tumors and reports alterations of the Wnt pathway, laying the basis for further investigation on JCPyV-mediated oncogenesis in the brain.

Indexed as

beta CateninBrain NeoplasmsJC VirusWnt Signaling PathwayAdolescentAntigens, Viral, TumorCapsid ProteinsChildChild, PreschoolCyclin D1DNA, ViralFemaleHumansInfantMaleMicroRNAsAntigens, Viral, Tumorbeta CateninCapsid ProteinsCCND1 protein, humanCTNNB1 protein, humanCyclin D1DNA, ViralMicroRNAsMYC protein, humanProto-Oncogene Proteins c-mycVP1 protein, polyomavirusBrain tumorsJC polyomavirusOncogenesisWnt/ß-catenin pathway

Identifiers

PMID40960726
PMCPMC12618385

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.