Evidence map›Paper›PMID 40960592›Full record

ArticleMolecular diversity2026

Discovery of novel Plasmodium falciparum PfDHFR-TS inhibitors from ConMedNP natural compounds: a multi-computational approach.

Victorien Hermann Haiwang Djefoulna, Maxime Atiya Atiya, Jean Jules Fifen, Jeanet Conradie

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Victorien Hermann Haiwang DjefoulnaQuantum Theory and Applications Unit, Department of Physics, Faculty of Science, University of Ngaoundere, P.O. Box 454, Ngaoundere, Cameroon. haiwanghermann@gmail.com.
Maxime Atiya AtiyaQuantum Theory and Applications Unit, Department of Physics, Faculty of Science, University of Ngaoundere, P.O. Box 454, Ngaoundere, Cameroon.
Jean Jules FifenQuantum Theory and Applications Unit, Department of Physics, Faculty of Science, University of Ngaoundere, P.O. Box 454, Ngaoundere, Cameroon. julesfifen@gmail.com.
Jeanet ConradieDepartment of Chemistry, University of the Free State, P.O Box 339, Bloemfontein, Free State, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise of drug-resistant Plasmodium falciparum necessitates novel antimalarial therapies. Leveraging the ConMedNP database, which includes over 3119 natural compounds from Central and West African medicinal plants, this study targets Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS), a vital enzyme for parasite survival. Molecular docking of 2754 compounds revealed a mean binding affinity of

Indexed as

AntimalarialsBiological ProductsDrug DiscoveryEnzyme InhibitorsPlasmodium falciparumProtozoan ProteinsTetrahydrofolate DehydrogenaseThymidylate SynthaseMolecular Docking SimulationMultienzyme ComplexesQuantitative Structure-Activity RelationshipAntimalarialsBiological ProductsEnzyme InhibitorsMultienzyme ComplexesProtozoan ProteinsTetrahydrofolate DehydrogenaseThymidylate Synthasethymidylate synthase-dihydrofolate reductaseADMETAntimalarial drugsConMedNP databaseDFTMolecular dockingMolecular dynamicsPfDHFR-TSPlasmodium falciparumQSAR

Identifiers

PMID40960592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.