ArticleCell biochemistry and biophysics2026
Green-Synthesized Selenium Nanoparticles Incorporated in Alginate/Casein Hydrogel for Targeted Cancer Therapy: Enhancing Therapeutic Index and Reducing Toxicity.
Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Recent Developments in Protein-Based Hydrogels for Advanced Drug Delivery Applications.Pharmaceutics · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rising incidence of colon cancer necessitates the development of novel therapeutic strategies that are both effective and environmentally sustainable. This study explores the green synthesis of multifunctional selenium nanoparticles (SeNPs), which have shown promise as photothermal agents and photosensitizers. SeNPs were synthesized using an eco-friendly method with plant extracts as reducing agents, aiming to reduce toxicity, combat drug resistance, and enhance biocompatibility.We formulated a selenium-loaded alginate/casein hydrogel (Se-Loaded Alg/Cas NPs) specifically for photothermal therapy in colon cancer. Integrating SeNPs into the hydrogel allows for precise controlled release mechanisms and significantly improves biocompatibility, paving the way for safer therapeutic applications. This approach enhances the structural integrity and stability of SeNPs, facilitates functionalization with complementary therapeutic agents, and ensures biodegradability for natural clearance from the body. The hydrogels also promote cell adhesion and proliferation, which aids in healing adjacent healthy tissues and can be designed for stimuli-responsive behavior.Characterization showed that Se-Loaded Alg/Cas NPs exhibited uniform spherical morphology and distinct crystalline structure, producing SeNPs with an average size of 18 ± 2 nm and Se-Loaded Alg/Cas NPs at 55 ± 6 nm. Zeta potential assessments indicated negative surface charges, with values of -21.4 ± 3.2 mV for SeNPs and − 62.3 ± 10.4 mV for Se-Loaded Alg/Cas NPs. In vitro cytotoxicity studies revealed that SeNPs had weak anticancer activity (IC50 of 75.95 µg/ml), while the hydrogel showed significant activity (IC50 of 4.90 µg/ml) against the colorectal carcinoma cell line (HCT116). Se-Loaded Alg/Cas NPs, combined with near-infrared (NIR) laser irradiation, effectively inhibited cell proliferation, demonstrating their potential for targeted drug delivery through chemotherapy and photothermal therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.