Evidence map›Paper›PMID 40960577›Full record

ArticleInflammopharmacology2025

The impact of alpha-lipoic acid treatment on various mediators of inflammatory and immune responses in a murine arthritis model.

Mohamad M Aboelenin, Mohamed Hefnawy, Talha Bin Emran, Heba I Shafey, Khairy M A Zoheir

Abstract read
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Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohamad M AboeleninCell Biology Department, Biotechnology Research Institute, National Research Centre, Dokki, 12622, Giza, Egypt.
Mohamed HefnawyDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Talha Bin EmranDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, 02912, USA.
Heba I ShafeyCell Biology Department, Biotechnology Research Institute, National Research Centre, Dokki, 12622, Giza, Egypt.
Khairy M A ZoheirCell Biology Department, Biotechnology Research Institute, National Research Centre, Dokki, 12622, Giza, Egypt. khma25@gmail.com.ORCID http://orcid.org/0000-0003-0896-4499

Funding

King Saud University RSPD2025R754
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by inflammation in the synovial lining of joints, leading to pain, stiffness, and significant functional limitations. Current treatments focus on managing symptoms and slowing disease progression, but they often have side effects and may not be effective for all patients. This study investigated the effects of alpha-lipoic acid (ALA) on immune response and inflammation in mouse model of arthritis. Adjuvant-induced arthritis (AIA) was established in mice, and ALA was administered to mice at a dose of 75 mg/kg via oral gavage twice daily for 7 consecutive days. ALA administration significantly reduced arthritis severity, as evidenced by decreased paw oedema and arthritis score. ALA treatment led to a significant reduction in plasma levels of IL-17A, TNF-α, and MMP-3, key biomarkers of arthritis disease activity. ALA decreased the number of circulating Th17 and NF-κB p65

Indexed as

Arthritis, ExperimentalArthritis, RheumatoidInflammationInflammation MediatorsThioctic AcidAnimalsAnti-Inflammatory AgentsCytokinesDisease Models, AnimalMaleMiceMolecular Docking SimulationTh17 CellsAnti-Inflammatory AgentsCytokinesInflammation MediatorsThioctic AcidAlpha-lipoic acidGene expressionImmune responsesInflammationRheumatoid arthritis

Identifiers

PMID40960577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.