ArticleEJNMMI research2025
In ovo model with emu eggs as novel alternative to animal testing in preclinical imaging research.
Article in EJNMMI research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- PHYTO-PET - Imaging plant physiology on a long-axial field-of-view PET scanner.European journal of nuclear medicine and molecular imaging · 2026Article
- In-Ovo Imaging with Ostrich Eggs: Eggshell Attenuation in CT and Limitations of Organ Dosimetry.Molecular imaging and biology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLarge-size in ovo models are receiving increasing attention since they comply with the 3R requirements (Replacement, Reduction and Refinement) by limiting the number of fully developed laboratory animals. In preclinical imaging research, a specific advantage is that they do not require dedicated scanners for small animals (expensive and rarely available) but are suitable for imaging studies by scanners used for clinical examinations. The present study evaluated large-sized fertilized emu eggs as a candidate model for preclinical imaging research in nuclear medicine by [
resultsOf 31 fertilized eggs, 18 eggs had viable peripheral vasculature available for vessel detection via MRI or CT. Both modalities provided reliable information on location and dimension of target blood vessels. Optimization of catheterization proved challenging, and only 5 [
conclusionThe emu egg model is suitable for preclinical imaging research with clinical scanners. Considering the shorter seasonal availability but longer incubation period of fertilized emu eggs, this model is a valid complement to the recently introduced ostrich egg model, available only in warm periods. In combination, these models offer a year-round flexibility for in ovo imaging research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.