Evidence map›Paper›PMID 40960555›Full record

ArticleClinical oral investigations2025

Bioactive glass products for the treatment of dentin hypersensitivity: a scoping review.

João Vitor do Nascimento Santos, Pablo Winícius Sousa de Moraes, Matheus Nobrega Pereira, Juan Vitor Costa Leite, Gabriela de Alencar Pinto Magalhães, Kim Capehart, Ana Karina Maciel de Andrade, Renally Bezerra Wanderley E Lima

Abstract readScoping Review
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

João Vitor do Nascimento SantosDepartment of Dentistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.ORCID http://orcid.org/0000-0003-2421-0582
Pablo Winícius Sousa de MoraesDepartment of Restorative Dentistry, Federal University of Paraiba, Campus I Lot. Cidade Universitária, João Pessoa, Paraíba, Brazil.ORCID http://orcid.org/0009-0009-3094-6191
Matheus Nobrega PereiraDepartment of Restorative Dentistry, Federal University of Paraiba, Campus I Lot. Cidade Universitária, João Pessoa, Paraíba, Brazil.ORCID http://orcid.org/0000-0003-3246-4689
Juan Vitor Costa LeiteDental Materials Division, Departament of Restorative Dentistry, Piracicaba Dental School, State University of Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-6069-6703
Gabriela de Alencar Pinto MagalhãesDepartment of Restorative Sciences, Dental College of Georgia at Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0002-7001-8850
Kim CapehartDepartment of General Dentistry, Dental College of Georgia at Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0002-5234-6500
Ana Karina Maciel de AndradeDepartment of Restorative Dentistry, Federal University of Paraiba, Campus I Lot. Cidade Universitária, João Pessoa, Paraíba, Brazil.ORCID http://orcid.org/0000-0003-4520-5176
Renally Bezerra Wanderley E LimaDepartment of Restorative Dentistry, Federal University of Paraiba, Campus I Lot. Cidade Universitária, João Pessoa, Paraíba, Brazil. renallywanderley@gmail.com.ORCID http://orcid.org/0000-0003-4477-7850

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo systematically map and synthesize the current scientific evidence on the active ingredients and effectiveness of bioactive glass-containing products for the treatment of dentin hypersensitivity, and to identify knowledge gaps. MATERIALS AND

methodsThis scoping review followed PRISMA-ScR guidelines and was registered on the Open Science Framework platform. Searches were conducted in PubMed/MEDLINE, Embase, Scopus, and Web of Science up to March 2025. Studies of any evidence level investigating bioactive glasses, bioactive glass-ceramics, or related products for dentin hypersensitivity treatment, evaluating parameters like dentinal tubule occlusion, dental remineralization, or pain relief, were included. Descriptive analysis was applied to all included studies.

resultsA total of 72 studies were reviewed, primarily in vitro (n = 46), with randomized clinical trials (n = 17) and reviews (n = 9) also represented. Calcium sodium phosphosilicate was the most analyzed bioactive glass (n = 33), often compared with arginine, nano-hydroxyapatite, potassium nitrate, and strontium acetate formulations. Products were commonly presented as toothpaste (n = 39), powder (n = 14), and gel (n = 6). In vitro studies frequently reported benefits in dentinal tubule occlusion, predominantly assessed by scanning electron microscopy. Clinical studies demonstrated reductions in dentin hypersensitivity-related pain, commonly assessed using air jet or cold-water stimuli combined with Visual Analog Scale (VAS) scores or the Schiff Cold Air Sensitivity Scale (SCSS), with follow-up periods ranging from 1 to 11 weeks.

conclusionToothpaste containing calcium sodium phosphosilicate was the most extensively studied bioactive glass-based product for dentin hypersensitivity treatment, with in vitro evidence supporting its effectiveness. Additional clinical research is needed to confirm these findings. CLINICAL SIGNIFICANCE: Bioactive glass products show promise in the treatment of dentin hypersensitivity. Given the variability in composition, evidence-based selection is key to ensuring effective treatment and improving patient outcomes.

Indexed as

CeramicsDentin Desensitizing AgentsDentin SensitivityGlassHumansToothpastesDentin Desensitizing AgentsToothpastesBioactive glassesBiocompatible materialsDentinal tubule occlusionDentin hypersensitivity

Identifiers

PMID40960555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.