ArticleFish physiology and biochemistry2025
Salinity-dependent responses differentiate branchial ion regulation during acute hypothermal stress in euryhaline Indian Medaka.
Article in Fish physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gill function in gas exchange and ion regulation is crucial for ionoregulatory homeostasis in teleost fishes, yet further research is needed to elucidate how cold stress affects these processes, particularly in relation to salinity-dependent tolerability. Indian medaka (Oryzias melastigma) were acclimated to freshwater (FW) and seawater (SW) environments before being exposed to cold stress at 18 °C for 168 h. The protein abundance of the apoptotic marker Caspase-3 increased significantly in SW-acclimated fish compared to controls, indicating a heightened apoptotic response under cold stress in SW conditions. Concurrently, the expression of the anti-apoptotic gene birc5 exhibited distinct patterns in FW and SW, suggesting differential regulatory mechanisms in response to cold exposure. Transcriptomic analysis revealed that cold stress significantly influenced genes related to ion regulation, osmoregulation, and cellular metabolism, with distinct pathways activated in FW and SW environments. Notably, SW-specific genes were predominantly involved in metabolic pathways and stress signaling, while FW-specific genes were linked to transport processes and cellular maintenance. Additionally, cold stress significantly affected the expression of Na
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