ReviewArchives of gynecology and obstetrics2025
Reductive stress and the role of antioxidants in male infertility: a narrative review.
Review in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmacologic and Nutritional Therapies in Idiopathic Male Infertility: A Systematic Review and Meta-Analysis.Andrology · 2026Pooled it
- Platelet-Derived Growth Factor Receptor Alpha in Male Reproductive Health and Oxidative Stress: Stromal Homeostasis, Injury, and Research Perspectives.Antioxidants (Basel, Switzerland) · 2026Review
- Astaxanthin and Male Reproductive Health: Mechanisms, Experimental Evidence, and Clinical Perspectives.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Spinal Cord Injury-Related Male Infertility: Oxidative Stress, Inflammation, and Sperm DNA Damage.Journal of clinical medicine · 2026Review
- Oxidative Stress and Male Infertility: A Critical Analysis of Current Diagnostic and Therapeutic Methods.Antioxidants (Basel, Switzerland) · 2026Review
- Reactive Oxygen and Nitrogen Species in Male Reproductive Health: From Molecular Mechanisms to Clinical Consequences.Antioxidants (Basel, Switzerland) · 2026Review
- Urolithin A improves motility, antioxidant defense, and mitochondrial function of chilled canine spermatozoa during 72-h liquid storage.Scientific reports · 2026Article
- A systematic review of microgravity on reproductive systems: Implications for space biology and human health.iScience · 2026Review
- Oxidative Stress and Inflammatory Biomarkers in Male Infertility: A Narrative Review of Diagnostic Value and Clinical Integration.Diagnostics (Basel, Switzerland) · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ability of antioxidant therapy to mitigate oxidative stress (OS)-induced sperm function impairment makes it a popular treatment for male infertility. Reductive stress (RS), a condition characterized by an overcompensation in redox balance that favors reduction over oxidation, may be brought on by excessive or extended antioxidant use, according to mounting evidence. The purpose of this review is to examine the processes by which an excess of antioxidants causes RS and to evaluate any potential negative impacts on men's reproductive health.
methodsA comprehensive overview of recent clinical and experimental studies focused on the effects of excessive antioxidant use on redox biology, mitochondrial function, spermatogenesis, and sperm quality.
resultsRS has been shown to affect sperm growth and function, interfere with cellular signaling, and damage mitochondrial integrity. Antioxidants are commonly employed, although there are currently no clear clinical guidelines or biomarkers for diagnosis to monitor redox equilibrium.
conclusionsIn male infertility treatments based on antioxidants, RS poses a paradoxical risk. A personalized, balanced approach to antioxidant therapy is essential, alongside the development of biomarkers and standardized protocols to ensure redox homeostasis and avoid potential harm.
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Registered trials
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