ArticleClinical neuroradiology2026
Non-invasive Prediction of Meningioma Tumor Grade by Quantification of Shape-based Radiomics Features and Surface Regularity.
Article in Clinical neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- CT imaging of thyroid cartilage invasion in glottic laryngeal cancer: correlation of traditional semiotics and texture analysis with histopathology.La Radiologia medica · 2026Article
- Preoperative Prediction of TACE Refractoriness in Hepatocellular Carcinoma Using CT-Based Radiomics Model.Journal of hepatocellular carcinoma · 2026Article
- MRI Reflects Meningioma Biology and Molecular Risk.Cancers · 2025Article
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12 authors.
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Abstract
purposePrognosis and therapeutic approaches to meningiomas are determined by their proliferative activity and tumor grade. The early identification of aggressive phenotypes is hence essential to improving outcomes. Here, we investigated the potential of shape-based radiomics features and surface regularity (SR) as non-invasive biomarkers of atypical (grade 2) and anaplastic (grade 3) meningiomas.
methodsIn this retrospective single-center study, we assessed individuals with treatment-naive meningiomas in a comprehensive analysis of MR imaging with histopathological grading and quantification of mitotic activity. Radiomics (sphericity, elongation, flatness) and SR measures were calculated on segmented contrast-enhancing tumor components and tested for association with WHO grade (n = 62 grade 1, n = 71 grade 2, and n = 19 grade 3) and proliferation.
resultsAll tumor grades were significantly different in characteristics of sphericity and SR with decreasing values at higher tumor grades as an expression of a more irregular shape. Additionally, radiomics features of tumor elongation and flatness discriminated grade 3 cases from grade 1 (p = 0.0008 and p = 0.0003) and grade 2 meningiomas (p = 0.0008 and p = 0.0013). Mitotic activity exhibited a significant negative correlation with the four imaging markers assessed (p < 0.003).
conclusionShape-based radiomics features of sphericity and SR can serve as preoperative grading biomarkers of meningiomas in routine contrast-enhanced T1w MRI.
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