ArticleAutophagy2025
Aggregate fragmentation: the ticket to aggrephagy.
Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Human Hsp70 paralogs display selective J-domain interactions tuning proteostasis under stress.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies.Frontiers in cellular neuroscience · 2026Review
- Recent insights into HSP70: proteostasis and beyond.Frontiers in molecular biosciences · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our recent study identifies a previously unrecognized requirement for protein aggregate fragmentation as a prerequisite for autophagic clearance of amorphous aggregates, a process that has been termed aggrephagy. We show that aggregate fragmentation depends on two distinct but cooperative components: the DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6)-HSPA/HSP70 (heat shock protein family A (Hsp70))-HSPH1/HSP110 chaperone module and the 19S regulatory particles (RPs) of the proteasome. These factors act together to not only to fragment protein aggregates but also to compact them, enabling clustering of selective autophagy receptors (SARs) and subsequent local phagophore formation. Our results show that this fragmentase activity plays a role in the aggrephagic clearance of different aggregate species, including disease-related HTT (huntingtin) aggregates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.