ArticleAutophagy2025
ATG8ylation-orchestrated vacuolar membrane remodeling facilitates plant alkaline stress tolerance.
Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Genome-Wide Identification of SNF7 Gene Family in Maize and Potential Roles in Response to Abiotic and Biotic Stress.International journal of molecular sciences · 2026Article
- Plant-Derived Nanovesicles: A Comprehensive Review from Isolation to Clinical Translation-Unlocking Natural Nanocarriers for Biomedical Applications.Biomolecules · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While ATG8ylation, the C-terminal lipidation of mammalian and plant Atg8 (ATG8)-family proteins, is a well-established driver of autophagosome formation, emerging evidence reveals its non-canonical role in modifying single-membrane organelles under diverse environmental stresses. In a recent study, we found that disruption of the vacuolar proton gradient by alkaline stress rapidly triggers the translocation of ATG8 to the vacuolar membrane in plants. ATG8ylation facilitates membrane invagination through a mechanism independent of both ESCRT and the cytoskeleton. Concurrently, ATG8 recruits ATG2 to endoplasmic reticulum (ER)-vacuolar membrane contact sites, a process that may contribute to damaged membrane repair. Together, these processes enable plants to rapidly recover from vacuolar pH imbalance and adapt to alkaline conditions. Our findings advance the understanding of ATG8ylation in vacuolar membrane homeostasis and damage response, highlighting its conserved role in organellar stability and stress adaptation.
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Registered trials
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