Evidence map›Paper›PMID 40960436›Full record

ArticleJACC. Case reports2025

Recurrent Left-Sided Stroke: Caseous Mitral Annulus Necrosis Versus Aortic Valve Lambl's Excrescences.

Khadijah T Hussain, Najah Khan, Poulina Q Uddin

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Khadijah T HussainScripps Mercy Hospital, San Diego, California, USA. Electronic address: Khadijahhussain96@gmail.com.
Najah KhanCalifornia Department of Cardiology, Scripps Clinic, San Diego, California, USA.
Poulina Q UddinCalifornia Department of Cardiology, Scripps Clinic, San Diego, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStroke management proves challenging with caseous necrotic mitral valve and aortic valve Lambl's excrescences. CASE SUMMARY: A 68-year-old woman presented with right-sided weakness. Four months prior, she had a left middle cerebral artery cerebrovascular accident and was started on aspirin, clopidogrel, statin, and angiotensin receptor blocker. New left-sided infarcts were identified, without significant carotid disease. Findings on transesophageal echocardiography indicated severe triple-vessel coronary artery disease, mitral caseous necrosis without valvular dysfunction, and Lambl's excrescences. Clopidogrel was switched to apixaban, and a loop recorder was placed. Coronary revascularization was deferred, with plans for surgical management of the Lambl's excrescences. DISCUSSION: Recurrent left-sided strokes without significant carotid disease suggest a cryptogenic etiology. Caseous mitral necrosis and Lambl's excrescence are uncommon causes of cardioembolic stroke, but they must be considered. Management is not standardized but typically involves antiplatelets or anticoagulation, and surgical options must also be discussed.

Indexed as

aortic valveechocardiographymitral valvestroke

Identifiers

PMID40960436
PMCPMC12793846

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.