Evidence map›Paper›PMID 40960318›Full record

ArticleJournal of virology2025

Mutation in enterovirus 71 nonstructural protein 3A increases genome replication fidelity and exhibits attenuated virulence in mice.

Fang Yu, Dongyan Xiong, Yao Zhong, Qiu-Yan Zhang, Cheng-Lin Deng, Zhe-Rui Zhang, Chang Wang, Yang Qiu, Han-Qing Ye, Peng Gong and 1 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fang YuState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.ORCID 0009-0009-3445-7571
Dongyan XiongState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Yao ZhongState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Qiu-Yan ZhangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Cheng-Lin DengState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Zhe-Rui ZhangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Chang WangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Yang QiuState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Han-Qing YeState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Peng GongState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.ORCID 0000-0002-8264-7523
Bo ZhangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.ORCID 0000-0002-8895-3679

Funding

Hubei Provincial Natural Science Foundation of China 2025AFB822National Key Research and Development Program of China 2022YFD1800100National Natural Science Foundation of China 32100110National Natural Science Foundation of China/Hong Kong Research Grants Council Joint Research Program 3231101030
6 · The paper itself

Abstract

Increasing numbers of studies have highlighted the important implications of the replication fidelity of RNA viruses for virus replication, pathogenesis, and the development of antiviral drugs and live-attenuated vaccines. However, most of the research has focused on viral polymerase, and little information is available about the potential role of other viral replicase proteins. Here, we demonstrated that the mutations of 3A

Indexed as

Enterovirus A, HumanEnterovirus InfectionsMutationViral Nonstructural ProteinsVirus ReplicationAnimalsDisease Models, AnimalGenome, ViralHumansMiceRNA-Dependent RNA PolymeraseRNA, ViralVero CellsVirulenceRNA-Dependent RNA PolymeraseRNA, ViralViral Nonstructural Proteinsdeep sequencinghelix unwinding activityreplication fidelityRNA synthesisvirulence

Identifiers

PMID40960318
PMCPMC12548465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.