Evidence map›Paper›PMID 40960283›Full record

ArticleImmunology2026

Mitochondrial Activity Regulates Human T Helper 17 Differentiation and Function.

Xinlai Chen, Theodoros Ioannis Papadimitriou, Anne H G van Essen, Britt van Brunschot, Monique M Helsen, Annet Sloetjes, Elly L Vitters, Werner J H Koopman, Peter M van der Kraan, Arjan P M van Caam and 1 more

Abstract read
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In one paragraph

Article in Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xinlai ChenDepartment of Rheumatology and Laboratory of Experimental Rheumatology, Radboudumc, Nijmegen, the Netherlands.ORCID 0009-0001-2127-0590
Theodoros Ioannis PapadimitriouDepartment of Rheumatology and Laboratory of Experimental Rheumatology, Radboudumc, Nijmegen, the Netherlands.
Anne H G van EssenDepartment of Rheumatology and Laboratory of Experimental Rheumatology, Radboudumc, Nijmegen, the Netherlands.
Britt van BrunschotDepartment of Rheumatology and Laboratory of Experimental Rheumatology, Radboudumc, Nijmegen, the Netherlands.
Monique M HelsenDepartment of Rheumatology and Laboratory of Experimental Rheumatology, Radboudumc, Nijmegen, the Netherlands.
Annet SloetjesDepartment of Rheumatology and Laboratory of Experimental Rheumatology, Radboudumc, Nijmegen, the Netherlands.
Elly L VittersDepartment of Rheumatology and Laboratory of Experimental Rheumatology, Radboudumc, Nijmegen, the Netherlands.
Werner J H KoopmanDepartment of Pediatrics, Amalia Children's Hospital, Radboudumc, Nijmegen, the Netherlands.
Peter M van der KraanDepartment of Rheumatology and Laboratory of Experimental Rheumatology, Radboudumc, Nijmegen, the Netherlands.
Arjan P M van CaamDepartment of Rheumatology and Laboratory of Experimental Rheumatology, Radboudumc, Nijmegen, the Netherlands.
Marije I KoendersDepartment of Rheumatology and Laboratory of Experimental Rheumatology, Radboudumc, Nijmegen, the Netherlands.

Funding

China Scholarship Council 202107720099
6 · The paper itself

Abstract

Immunometabolism plays a pivotal role in T cell fate decisions, yet its specific contribution to human Th17 differentiation remains incompletely understood. Th17 cells, a subset of CD4

Indexed as

Cell DifferentiationMitochondriaTh17 CellsCells, CulturedDynaminsGlycolysisGTP PhosphohydrolasesHumansLymphocyte ActivationMembrane Potential, MitochondrialMitochondrial DynamicsMitochondrial ProteinsOxidative PhosphorylationSignal TransductionDNM1L protein, humanDynaminsGTP PhosphohydrolasesMFN2 protein, humanMitochondrial Proteinsmitochondrial activityT cell exhaustionT cell metabolismTh17 cellsTh17 differentiation

Identifiers

PMID40960283
PMCPMC12665803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.