Evidence map›Paper›PMID 40960275›Full record

ArticleThe International journal of eating disorders2025

Within-Person Changes in Daily Ovarian Hormone Levels Influence Genetic Effects on Emotional Eating in Women.

Megan E Mikhail, Kristen M Culbert, Pamela K Keel, S Alexandra Burt, Cheryl L Sisk, Alexander Johnson, Steven Boker, Micheal C Neale, Kelly L Klump

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The International journal of eating disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Megan E MikhailDepartment of Psychology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0001-9262-3683
Kristen M CulbertDepartment of Psychology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-9139-6068
Pamela K KeelDepartment of Psychology, Florida State University, Tallahassee, Florida, USA.ORCID 0000-0001-6542-5147
S Alexandra BurtDepartment of Psychology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0001-5538-7431
Cheryl L SiskDepartment of Psychology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-4642-607X
Alexander JohnsonDepartment of Psychology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0001-8166-7189
Steven BokerDepartment of Psychology, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-2117-8548
Micheal C NealeDepartments of Psychiatry, Human Genetics, and Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID 0000-0003-4887-659X
Kelly L KlumpDepartment of Psychology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0003-1790-9264

Funding

National Science Foundation Graduate Research FellowshipNIMH NIH HHS 082054NIMH NIH HHS 111715NIMH NIH HHS 128196
6 · The paper itself

Abstract

introductionOvarian hormones (i.e., estradiol, progesterone) show robust phenotypic associations with binge eating and related behaviors (e.g., emotional eating) in females. Recent research suggests these associations may be due to ovarian hormone effects on genetic and environmental influences on dysregulated eating. However, no research has yet examined how within-person fluctuations in hormone levels impact genetic/environmental influences on day-to-day changes in dysregulated eating from an individual's own mean. This omission is critical because phenotypic associations between ovarian hormones and dysregulated eating are strongest at a within-person level in adult women, suggesting potentially unique and important within-person effects.

methodParticipants from same-sex female twin pairs (N = 468) from the MSU Twin Registry provided measures of ovarian hormones and emotional eating daily for 49 consecutive days. We used continuous twin moderation models to examine how within-person centered estradiol and progesterone impacted genetic/environmental influences on within-person shifts in emotional eating.

resultsWithin-person fluctuations in estradiol and progesterone significantly moderated genetic influences on within-person changes in emotional eating. Stronger genetic influences were observed when the ratio of within-person estradiol to progesterone was in the moderate range.

conclusionCyclic, within-person changes in ovarian hormones may contribute to phenotypic changes in dysregulated eating across the menstrual cycle by dynamically regulating expression of underlying genetic risk. Genetic influences may be particularly pronounced under the hormonal conditions characteristic of the mid-luteal phase (i.e., moderate estradiol and progesterone).

Indexed as

EmotionsEstradiolFeeding BehaviorGene-Environment InteractionProgesteroneAdultEmotional EatingFemaleHumansMiddle AgedYoung AdultEstradiolProgesteronebinge eatingemotional eatingestradiolovarian hormonesprogesteronetwin modelswithin‐person

Identifiers

PMID40960275
PMCPMC12703227

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.