Evidence map›Paper›PMID 40960234›Full record

ArticleACS infectious diseases2025

Sulfonyl Homoserine Lactones Are Tunable Probes to Inhibit the Quorum Sensing Receptor RhlR and Reduce Swarming Motility in

Guadalupe Aguirre-Figueroa, Diana A Morales Mijares, Isabel D Cannell, Irene M Stoutland, Helen E Blackwell

Erratum issuedAbstract read
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In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Guadalupe Aguirre-FigueroaDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Diana A Morales MijaresDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Isabel D CannellDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Irene M StoutlandDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Helen E BlackwellDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.ORCID 0000-0003-4261-8194

Funding

Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Chemical Strategies to Modulate Intercellular Bacterial CommunicationR35GM131817 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Helen E. Blackwell · 2019 to 2026
$2.9M
Chemistry-Biology Interface Training ProgramT32GM152341 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Helen E. Blackwell · 2024 to 2026
$1.6M
NIGMS NIH HHS R35 GM131817NIGMS NIH HHS T32 GM008505NIGMS NIH HHS T32 GM152341
6 · The paper itself

Abstract

We report non-native small molecules capable of inhibiting a key quorum sensing receptor─RhlR─in the opportunistic pathogen

Indexed as

4-ButyrolactoneAnti-Bacterial AgentsBacterial ProteinsPseudomonas aeruginosaQuorum SensingTrans-Activators4-ButyrolactoneAnti-Bacterial AgentsBacterial Proteinshomoserine lactoneRhlR protein, Pseudomonas aeruginosaTrans-Activatorsautoinducerchemical probesGram-negative bacteriaintercellular communicationLuxI/LuxR-type quorum sensingvirulence

Identifiers

PMID40960234
PMCPMC12456999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.