Evidence map›Paper›PMID 40960215›Full record

Observational studyJournal of clinical hypertension (Greenwich, Conn.)2025

Long-Term Blood Pressure Variability and Physical Performance in Older Adults.

Kerry M Sheets, Katherine L Webb, Robyn L Woods, Suzanne G Orchard, Lawrence Beilin, Michelle A Fravel, Christopher M Reid, Kevan R Polkinghorne, Rory Wolfe, Zhen Zhou and 3 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical hypertension (Greenwich, Conn.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01038583 (Aspirin in Reducing Events in the Elderly), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01038583 unknown statusnot on this map

Aspirin in Reducing Events in the Elderly

TypeobservationalSponsorHennepin Healthcare Research InstituteRan2010 to 2024Enrolled19,114ConditionsFunctional Disability, Dementia, Heart Disease, StrokeArms100 mg enteric-coated aspirin, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Long-Term Blood Pressure Variability and Physical Performance in Older Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kerry M SheetsDepartment of Medicine, Hennepin Healthcare, Minneapolis, Minnesota, USA.ORCID 0000-0002-3492-2404
Katherine L WebbSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Suzanne G OrchardSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Lawrence BeilinMedical School Royal Perth Hospital, University of Western Australia, Perth, Western Australia, Australia.
Michelle A FravelDepartment of Pharmacy Practice and Science, College of Pharmacy, The University of Iowa, Iowa City, Iowa, USA.
Christopher M ReidSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Kevan R PolkinghorneSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Rory WolfeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Zhen ZhouSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Joanne RyanSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Anne M MurrayDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Michael E ErnstDepartment of Pharmacy Practice and Science, College of Pharmacy, The University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0003-0267-4888

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MCNEIL, JOHN JAMES · 2019 to 2023
$42.9M
Monash UniversityNational Health and Medical Research Council of Australia 1127060National Health and Medical Research Council of Australia 334047National Institute on Aging and the National Cancer Institute at the National Institutes of Health U01AG029824National Institute on Aging and the National Cancer Institute at the National Institutes of Health U19AG062682NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682Victorian Cancer Agency
6 · The paper itself

Abstract

High variability in long-term blood pressure (BPV) independently predicts cardiovascular disease and cognitive decline. Increased BPV and declining physical performance may share mechanistic pathways. However, associations of BPV with gait speed and grip strength have not been examined. We completed a gender-stratified analysis of 16 692 participants enrolled in ASPREE/ASPREE-XT. Systolic and diastolic BPV were estimated from baseline-year 2 (Y2); gait speed/grip strength were assessed every 1-2 years following this period. Linear mixed models examined gait speed/grip strength trajectories over a median of 7.3 years of follow-up after Y2. Following adjustment, men with SBPV in tertile 3 (T3) versus T1 had slower gait speed at Y2 (0.021 m/s slower) and greater declines in gait speed (0.003 m/s greater decline/year, p < 0.001). Women with SBPV in T3 versus T1 had slower gait speed at Y2 (0.018 m/s slower), but similar rates of gait speed decline. Men with higher SBPV had weaker grip strength at Y2 (0.994 kg weaker for BPV T3 vs. T1) and greater declines in grip strength (0.016 kg greater decline/year/5 mmHg increase in BPV, p = 0.006). Women with BPV in T3 versus T1 had 0.486 kg weaker grip strength at Y2, but similar rates of grip strength decline. Associations of DBPV and SBPV with gait speed/grip strength were largely consistent. In summary, we found that higher BPV was independently associated with slower gait speed and weaker grip strength cross-sectionally in men and women, but only associated with trajectories of gait speed and grip strength in men. Future studies should examine high BPV as a target to preserve physical performance. Trial Registration: ISRCTN number: ISRCTN83772183; ClinicalTrials.gov identifier: NCT01038583.

Indexed as

Blood PressureHypertensionPhysical Functional PerformanceAgedBlood Pressure DeterminationCardiovascular DiseasesFemaleGaitHand StrengthHumansMaleMiddle AgedSex FactorsWalking Speedblood pressure variabilitygait speedgrip strengthphysical performance

Identifiers

PMID40960215
PMCPMC12442049

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.