Evidence map›Paper›PMID 40960194›Full record

ArticleChemistryOpen2025

One-Pot Synthesis of Novel β-Carboline-{α-Acylaminoamide}-Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies.

Ankit Kumar Atri, Lavanya Khullar, Gobind Kumar, Sahil Mishra, Tamanna Dua, Vinay Singh, Kusum Harjai, Parvesh Singh, Vasundhara Singh

Abstract read
In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ankit Kumar AtriDepartment of Applied Sciences, Punjab Engineering College (Deemed to be University), Sector-12, Chandigarh, 160012, India.
Lavanya KhullarDepartment of Microbiology, Panjab University, Sector-25, Chandigarh, 160014, India.
Gobind KumarSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Sahil MishraSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Tamanna DuaDepartment of Applied Sciences, Punjab Engineering College (Deemed to be University), Sector-12, Chandigarh, 160012, India.
Vinay SinghDepartment of Applied Sciences, Punjab Engineering College (Deemed to be University), Sector-12, Chandigarh, 160012, India.
Kusum HarjaiDepartment of Microbiology, Panjab University, Sector-25, Chandigarh, 160014, India.
Parvesh SinghSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.ORCID 0000-0001-6742-6389
Vasundhara SinghDepartment of Applied Sciences, Punjab Engineering College (Deemed to be University), Sector-12, Chandigarh, 160012, India.ORCID 0000-0001-8639-2313

Funding

National Research Foundation SRUG2204092857
6 · The paper itself

Abstract

A new series of β-carboline-{α-acylaminoamide}-bisindole hybrids (12a-l) is designed and synthesized employing an atom-economical one-pot Ugi four-component reaction (U-4CR), affording the target compounds in good yields. All synthesized compounds (12a-l) are characterized by NMR, infrared, and mass spectrometry and evaluated for their antibacterial activity against both Gram-positive and Gram-negative strains. Notably, compounds 12b, 12g, and 12h display comparable minimum inhibitory concentrations values (302-303 µg mL

Indexed as

Anti-Bacterial AgentsCarbolinesDensity Functional TheoryIndolesAcinetobacter baumanniiDNA GyraseGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsMolecular Docking SimulationPseudomonas aeruginosaStructure-Activity RelationshipAnti-Bacterial AgentsCarbolinesDNA GyraseIndolesantibacterial agentsdensity functional theory studiesmolecular dockingmolecular hybridizationUgi reactionβ‐carbolines

Identifiers

PMID40960194
PMCPMC12680560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.