ArticleACS chemical biology2025
Characterization of Variation in Natural Product Production Under Chemical Elicitation Using Parallel Stable Isotope Labeling.
Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Inverse stable isotopic labeling for natural product characterization and discovery.Natural product reports · 2026Review
- Combating Antibacterial Resistance: The Integrative Role of Artificial Intelligence in Bio-Based Product Development.Antibiotics (Basel, Switzerland) · 2026Review
- Identification of Deoxy- andJournal of natural products · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Most microorganisms produce far fewer secondary metabolites under laboratory culture conditions than would be expected based on the number of biosynthetic gene clusters (BGCs) present in their genomes. One strategy for inducing secondary metabolite production is to add chemical elicitors that disrupt bacterial metabolism. This one-strain-many-compounds (OSMAC) strategy has been used successfully to discover a broad range of natural products. However, traditional strategies for detecting changes in natural product production are not well suited to characterizing variations in the full secondary metabolome under elicitation conditions. One efficient tool to differentiate metabolites between experiments is IsoAnalyst, a parallel stable isotope labeling method that connects secondary metabolites to BGCs by determining the rates of incorporation for a set of isotopically labeled secondary metabolism building blocks. In this study three strains of
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