Evidence map›Paper›PMID 40960112›Full record

Trial reportJournal of cosmetic dermatology2025

Phase I Clinical Trial: Evaluating the Efficacy, Safety, and Patient Satisfaction of Platelet-Rich Plasma (PRP) Injections and Microneedling for Androgenetic Alopecia Treatment.

Mohammad Ali Nilforoushzadeh, Masoumeh Roohaninasab, Elham Behrangi, Alireza Jafarzadeh, Maryam Nouri, Solmaz Zare, Sona Zare

Abstract readRandomized Controlled TrialClinical Trial, Phase IComparative Study
In one paragraph

Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammad Ali NilforoushzadehSkin Repair Research Center, Jordan Dermatology and Hair Transplantation Center, Tehran, Iran.
Masoumeh RoohaninasabDepartment of Dermatology, Hazrat Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Elham BehrangiDepartment of Dermatology, Hazrat Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Alireza JafarzadehSkin Repair Research Center, Jordan Dermatology and Hair Transplantation Center, Tehran, Iran.ORCID https://orcid.org/0000-0001-5878-9778
Maryam NouriSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Solmaz ZareLaser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sona ZareSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPlatelet-rich plasma (PRP) has been widely utilized in dermatological treatments, leading to the development of various administration methods. This study aims to evaluate and compare the effectiveness of PRP injections and microneedling techniques for treating androgenetic alopecia (AGA) in clinical practice. MATERIALS AND

methodsA total of 40 participants diagnosed with AGA, aged between 18 and 50 years, were randomly assigned to receive either PRP injections or microneedling treatments. Each patient underwent two treatment sessions, with a 1-month interval between them. Hair density and thickness measurements were performed using TrichoScan before treatment and 2 months after the final session. Statistical analysis was conducted using SPSS software.

resultsAmong the participants, 28.57% were male and 71.43% were female, with an average age of 40.2 years (±7.7). In the PRP injection group, hair count increased by approximately 62.4% (from 17.40 ± 2.074 to 28.26 ± 6.229), and hair thickness improved by 58.6% (from 58.0 ± 25.01 to 92.0 ± 16.31). In the microneedling group, hair count increased by 88.4% (from 14.71 ± 3.988 to 27.71 ± 4.499), while hair thickness improved by 51.3% (from 49.0 ± 11.30 to 74.14 ± 22.42). Although both groups showed statistically significant improvements (p < 0.05), the intergroup differences in hair count and thickness were not statistically significant (p > 0.05).

conclusionThe findings of this study confirm PRP as a viable treatment option for AGA. Both injection and microneedling methods provided therapeutic benefits. Additionally, microneedling appeared to enhance patient satisfaction and treatment tolerance.

Indexed as

AlopeciaCosmetic TechniquesDry NeedlingPlatelet-Rich PlasmaAdolescentAdultFemaleHairHumansMaleMiddle AgedNeedlesPatient SatisfactionPercutaneous Collagen InductionTreatment OutcomeYoung Adultandrogenetic alopeciainjectionmicroneedlingplatelet‐rich plasma

Identifiers

PMID40960112
PMCPMC12442246

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.