ArticleCancer medicine2025
Short- and Mid-Term Outcomes of Proximal Gastrectomy With Double-Tract Reconstruction Versus Total Gastrectomy in Early-Stage Proximal Gastric Cancer.
Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07635836 (Comparison of Gastroesophageal Reflux and Quality of Life Between Double-tract and Tubular Gastric Anastomosis in Proximal Gastric Cancer Patients), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Gastroesophageal Reflux and Quality of Life Between Double-tract and Tubular Gastric Anastomosis in Proximal Gastric Cancer Patients
Who cites it
2 citing papers in PubMed.
- Long-term quality of life, financial toxicity, and decision regret following therapeutic and prophylactic gastrectomy for cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Short- and Mid-Term Outcomes of Proximal Gastrectomy With Double-Tract Reconstruction Versus Total Gastrectomy in Early-Stage Proximal Gastric Cancer.Cancer medicine · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundTotal gastrectomy (TG) is the predominant approach for proximal gastric cancer; however, it frequently leads to various postoperative nutritional and metabolic disorders. Recently, double-tract reconstruction (DTR) following proximal gastrectomy (PG) has been developed to preserve gastric function and reduce postoperative reflux esophagitis. This study aimed to compare the outcomes of PG-DTR with those of TG in patients with proximal gastric cancer.
methodsPatients with clinically staged cT1 to cT2 proximal gastric cancer who underwent either PG-DTR or TG with Roux-en-Y reconstruction (TG-RY) were enrolled. Propensity score matching (PSM) was applied to reduce confounding bias. Surgical outcomes, nutritional status, reflux esophagitis, and prognosis were prospectively analyzed. Quality of life (QOL) was assessed at 3, 6, and 12 months postoperatively using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45).
resultsAfter PSM, 93 patients were included in each group (PG-DTR and TG-RY). The PG-DTR group had fewer retrieved lymph nodes than the TG-RY group. No significant differences were observed between the groups in operative time, blood loss, postoperative complications, length of hospital stay, reflux esophagitis, overall survival (OS), or disease-free survival (DFS). Female sex, preoperative BMI, TG-RY procedure, and severe postoperative complications (POCs) were identified as independent risk factors for malnutrition at 3 months postgastrectomy. Postoperatively, the TG-RY group exhibited significantly lower levels of hemoglobin, total protein, and albumin than the PG-DTR group. No differences were observed in postoperative QOL between the two groups, except for greater weight loss in the TG-RY group.
conclusionsCompared to TG-RY, PG-DTR was associated with improved postoperative nutritional status, including better body weight, hemoglobin, and albumin levels, in patients with early-stage proximal gastric cancer. Additionally, PG-DTR demonstrated comparable short-term outcomes, prognosis, and postoperative QOL to TG-RY, further supporting its viability as a surgical option.
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