ArticlePediatrics international : official journal of the Japan Pediatric Society
Evaluation of tri-ponderal mass index in predicting metabolic associated fatty liver disease in obese children.
Article in Pediatrics international : official journal of the Japan Pediatric Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Relationship between triglyceride-glucose-derived obesity indices and NAFLD in adolescents: A cross-sectional study.Medicine · 2026Article
- Evaluation of tri-ponderal mass index in predicting metabolic associated fatty liver disease in obese children.Pediatrics international : official journal of the Japan Pediatric SocietyArticle
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3 authors.
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Abstract
backgroundThis study aimed to evaluate the effectiveness of the tri-ponderal mass index (TMI) in identifying metabolic dysfunction-associated fatty liver disease (MAFLD) in obese children and adolescents.
methodsA total of 238 obese children and adolescents were included in the study. Evaluations included anthropometric measurements, liver function tests, lipid parameters, fasting glucose, insulin, and HOMA-IR. Logistic regression analysis was performed to determine the predictive value of TMI for MAFLD.
resultsMAFLD was diagnosed in 55.5% of participants. TMI values were significantly higher in the MAFLD group compared to those without MAFLD (mean TMI: 21.01 ± 3.05 vs. 20.14 ± 2.90, p = 0.026). In logistic regression analyses, male sex was an independent predictor in both models (OR = 3.10, p = 0.003 in the BMI-SDS model; OR = 2.63, p = 0.008 in the TMI model). HOMA-IR (OR = 1.10, p = 0.042; OR = 1.11, p = 0.029) and ALT (OR = 1.04, p = 0.002; OR = 1.05, p = 0.002) were also significant in both models. TMI was not independently associated with MAFLD (p = 0.249). TMI showed positive correlations with age, weight-SDS, BMI-SDS, fasting insulin, HbA1c, HOMA-IR, and the grade of hepatosteatosis.
conclusionWhile TMI values were higher in patients with MAFLD, TMI was not an independent predictor of MAFLD in obese children. Male sex, HOMA-IR, and ALT were consistently associated with MAFLD, suggesting greater predictive value. These findings suggest that TMI may have limited utility as a screening tool for MAFLD in pediatric clinical practice.
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