Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Lihong PanDepartment of Physiology and Biophysics (L.P., X.H., R.X., U.B., D.W., Z.N., J.S.C., J.S.S., Y.C.), University of Mississippi Medical Center, School of Medicine, Jackson.ORCID 0000-0002-1995-2373
Xiaochen HeDepartment of Physiology and Biophysics (L.P., X.H., R.X., U.B., D.W., Z.N., J.S.C., J.S.S., Y.C.), University of Mississippi Medical Center, School of Medicine, Jackson.ORCID 0000-0002-8266-5895
Rui XuDepartment of Physiology and Biophysics (L.P., X.H., R.X., U.B., D.W., Z.N., J.S.C., J.S.S., Y.C.), University of Mississippi Medical Center, School of Medicine, Jackson.ORCID 0009-0000-2265-5188
Umesh BhattaraiDepartment of Physiology and Biophysics (L.P., X.H., R.X., U.B., D.W., Z.N., J.S.C., J.S.S., Y.C.), University of Mississippi Medical Center, School of Medicine, Jackson.ORCID 0009-0003-4042-836X
Dongzhi WangDepartment of Physiology and Biophysics (L.P., X.H., R.X., U.B., D.W., Z.N., J.S.C., J.S.S., Y.C.), University of Mississippi Medical Center, School of Medicine, Jackson.
Hao WangUSF Health Heart Institute, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa (H.W.).ORCID 0000-0002-0834-3986
Ziru NiuDepartment of Physiology and Biophysics (L.P., X.H., R.X., U.B., D.W., Z.N., J.S.C., J.S.S., Y.C.), University of Mississippi Medical Center, School of Medicine, Jackson.
Heng ZengDepartment of Pharmacology and Toxicology (H.Z., J.-X.C.), University of Mississippi Medical Center, School of Medicine, Jackson.ORCID 0000-0001-8559-2807
John S ClemmerDepartment of Physiology and Biophysics (L.P., X.H., R.X., U.B., D.W., Z.N., J.S.C., J.S.S., Y.C.), University of Mississippi Medical Center, School of Medicine, Jackson.ORCID 0000-0003-2250-2960
Josh S SpeedDepartment of Physiology and Biophysics (L.P., X.H., R.X., U.B., D.W., Z.N., J.S.C., J.S.S., Y.C.), University of Mississippi Medical Center, School of Medicine, Jackson.ORCID 0000-0002-0131-5253
Jian-Xiong ChenDepartment of Pharmacology and Toxicology (H.Z., J.-X.C.), University of Mississippi Medical Center, School of Medicine, Jackson.ORCID 0000-0001-9203-4336
Yingjie ChenDepartment of Physiology and Biophysics (L.P., X.H., R.X., U.B., D.W., Z.N., J.S.C., J.S.S., Y.C.), University of Mississippi Medical Center, School of Medicine, Jackson.ORCID 0000-0002-4059-7847
Funding
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2013 to 2022
$23.4M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI John E Hall · 2023 to 2026
$6.3M
Mechanism of PD1 on cardiac inflammation resolution during heart failure developmentR01HL161085 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, YINGJIE · 2022 to 2025
$2.3M
Mechanisms of Treg and IL-35 in Regulating LV Failure-induced Lung Remodeling and Right Heart HypertrophyR01HL139797 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, YINGJIE · 2018 to 2021
backgroundCardiac inflammation is a key driver of cardiac fibrosis and heart failure. Cytotoxic CD8⁺ T cells play important roles in modulating inflammatory responses, especially during infections and autoimmune diseases. HIFs (hypoxia-inducible factors) regulate CD8⁺ T cell function and cardiac remodeling. However, the role of HIF in CD8⁺ T cells during heart failure development remains unclear.
methodsWe generated CD8⁺ T cell-specific PHD2 (prolyl hydroxylase domain protein 2)-deficient mice (PHD2
resultsUnder baseline conditions, PHD2 deletion in CD8⁺ T cells had no effect on heart function or effector molecule expression. Following transverse aortic constriction, PHD2
conclusionsPHD2 deletion in CD8⁺ T cells aggravates cardiopulmonary remodeling after pressure overload by enhancing CD8⁺ T cell activation and cytokine release via a HIF1α-dependent mechanism.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.