Evidence map›Paper›PMID 40959886›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Blood Pressure and Mortality in Mexico City: A Mendelian Randomization Study.

Michael Turner, Pablo Kuri-Morales, Jesús Alegre-Díaz, Paulina Baca, Jose Adrián Garcilazo-Ávila, Carlos González-Carballo, Raul Ramirez-Reyes, Fernando Rivas, Diego Aguilar-Ramírez, Fiona Bragg and 15 more

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Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Michael TurnerClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).
Pablo Kuri-MoralesInstituto Tecnológico y de Estudios Superiores de Monterrey, Mexico (P.K.-M.).ORCID 0000-0002-0704-9507
Jesús Alegre-DíazExperimental Research Unit, Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City (J.A.-D., P.B., J.A.G.-A., C.G.-C., R.R.-R., F.R., J.B.).ORCID 0000-0001-9390-3871
Paulina BacaExperimental Research Unit, Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City (J.A.-D., P.B., J.A.G.-A., C.G.-C., R.R.-R., F.R., J.B.).ORCID 0000-0002-0617-5931
Jose Adrián Garcilazo-ÁvilaExperimental Research Unit, Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City (J.A.-D., P.B., J.A.G.-A., C.G.-C., R.R.-R., F.R., J.B.).ORCID 0000-0002-9309-782X
Carlos González-CarballoExperimental Research Unit, Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City (J.A.-D., P.B., J.A.G.-A., C.G.-C., R.R.-R., F.R., J.B.).ORCID 0000-0001-5110-1563
Raul Ramirez-ReyesExperimental Research Unit, Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City (J.A.-D., P.B., J.A.G.-A., C.G.-C., R.R.-R., F.R., J.B.).
Fernando RivasExperimental Research Unit, Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City (J.A.-D., P.B., J.A.G.-A., C.G.-C., R.R.-R., F.R., J.B.).ORCID 0009-0004-7744-0044
Diego Aguilar-RamírezClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).
Fiona BraggClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0002-9181-6886
Louisa Gnatiuc FriedrichsClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0002-0641-2220
William G HerringtonClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0003-1172-8243
Michael HillClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0002-3861-6105
Eirini TrichiaClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0002-7655-5905
Alejandra Vergara-LopeClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0001-6262-2233
Rachel WadeClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0001-9826-6322
Doreen ZhuClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).
Rory CollinsClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0001-8288-8602
Richard PetoClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0001-8219-5339
Jaime BerumenExperimental Research Unit, Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City (J.A.-D., P.B., J.A.G.-A., C.G.-C., R.R.-R., F.R., J.B.).ORCID 0000-0001-6707-3317
Natalie StaplinClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0003-4482-4418
Jason TorresClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0002-7537-7035
Richard HaynesClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0002-1179-0023
Jonathan R EmbersonClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom (M.T., D.A.-R., F.B., L.G.F., W.G.H., M.H., E.T., A.V.-L., R.W., D.Z., R.C., R.P., N.S., J.T., R.H., J.R.E.).ORCID 0000-0001-7792-9422
Roberto Tapia-ConyerFaculty of Medicine, UNAM, Mexico City, Mexico (P.K.-M., R.T.-C.).ORCID 0000-0003-3814-2904

Funding

Medical Research Council MC_UU_00017/2Medical Research Council MR/Z504543/1Wellcome Trust
6 · The paper itself

Abstract

backgroundObservational studies relating blood pressure in middle age to mortality may underestimate lifelong effects. Mendelian randomization can reduce the impact of confounding and reverse causality and may better estimate lifelong effects of blood pressure on mortality.

methodsMendelian randomization analyses used 125 895 Mexico City Prospective Study participants aged 35 to 74 years at recruitment with valid genetic and other data. Cox regression, adjusted for confounders and regression dilution bias, related blood pressure to mortality in 133 027 participants aged 35 to 74 years without prior chronic disease (other than diabetes) at recruitment.

resultsIn the genetic analyses (40 560 [32%] men; mean age 50 years, mean body mass index 29 kg/m

conclusionsIn this Mexican population, genetically informed lifelong differences in blood pressure were strongly related to death from cardiovascular and kidney disease.

Indexed as

Blood PressureCardiovascular DiseasesHypertensionAdultAgedCause of DeathFemaleHumansMaleMendelian Randomization AnalysisMexicoMiddle AgedProspective StudiesRisk Factorsblood pressurecardiovascular diseaseshumanskidneyMexicoprospective studies

Identifiers

PMID40959886
PMCPMC7618184

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